184047-12-9Relevant articles and documents
A stereodivergent synthesis of chiral 4,5-disubstituted bis(oxazolines)
Desimoni, Giovanni,Faita, Giuseppe,Mella, Mariella
, p. 13649 - 13654 (2007/10/03)
Bis(oxazolines), disubstituted in the 4 and 5 positions, are synthesized from dimethylmalonyl bis-diamides of the suitable 1,2-disubstituted chiral aminoethanol. Starting from the same diamide, the ring closure can be realized either with retention (reflux in xylene with dibutyl tin dichloride - the Masamune protocol) or inversion (conversion into the mesylate and reflux with aqueous ethanolic NaOH) of the configuration at the chiral center in position 5.