184105-51-9Relevant articles and documents
3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors
Zhou, Nian E.,Guo, Deqi,Thomas, George,Reddy, Andhe V. N.,Kaleta, Jadwiga,Purisima, Enrico,Menard, Robert,Micetich, Ronald G.,Singh, Rajeshwar
, p. 139 - 141 (2003)
A new class of inhibitors for cysteine proteases cathepsin B, L, K and S is described. These inhibitors are based on the β-lactam ring designed to interact with the nucleophilic thiol of the cysteine in the active site of cysteine proteases. Some 3-acylamino-azetidin-2-one derivatives showed very potent inhibition activities for cathepsins L, K and S at the nanomolar or subnanomolar IC50 values.