184110-41-6

Basic information

• Product Name: (R)-(-)-2-[(RS)-1-ETHOXYETHOXY]-1-PROPANOL
• Synonyms: (R)-(-)-2-[(RS)-1-ETHOXYETHOXY]-1-PROPANOL
• CAS NO: 184110-41-6
• Molecular Formula: C₇H₁₆O₃
• Molecular Weight: 148.2
• Mol File: 184110-41-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 0.951 g/mL at 20 °C(lit.)
• Refractive Index: n20/D1.420
• BRN: 7566593
• CAS DataBase Reference: (R)-(-)-2-[(RS)-1-ETHOXYETHOXY]-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-2-[(RS)-1-ETHOXYETHOXY]-1-PROPANOL(184110-41-6)
• EPA Substance Registry System: (R)-(-)-2-[(RS)-1-ETHOXYETHOXY]-1-PROPANOL(184110-41-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 184110-41-6(Hazardous Substances Data)

Upstream product

• 255826-50-7 (2R,1'R/S)-Methyl 2-(1'-ethoxyethoxy)propanoate 
• 37101-80-7 2-(1-ethoxy-ethoxy)-propionic acid ethyl ester 

Relevant articles and documents

PROCESS FOR THE PRODUCTION OF ALKANEDIOL DERIVATIVES

The present invention provides a process for producing an alkanediol derivative represented by the general formula (II) from an ester compound represented by the general formula (I), safely without giving rise to racemization. The present invention lies in a process for producing an alcohol derivative represented by the following general formula (II): (wherein R2 and R3 are each independently a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; X is a hydrogen atom or a protecting group for hydroxyl group; and n is 0 or 1), which process comprises reducing an ester compound represented by the following general formula (I): (wherein R1 is an alkyl group having 1 to 4 carbon atoms; and R2, R3, X and n have the same definitions as given above) with sodium borohydride in a mixed solvent of at least one kind of solvent selected from the group consisting of aromatic hydrocarbons, aliphatic hydrocarbons and alicyclic hydrocarbons and a primary alcohol.

Synthesis and antiretroviral evaluation of new alkoxy and aryloxy phosphate derivatives of 3'-azido-3'-deoxythymidine

A series of new ether lipid-3'-azido-3'-deoxythymidine (AZT) conjugates (11a-g) were synthesized and evaluated for anti-HIV activity. The effect of chirality on the antiviral activity was examined through the synthesis of AZT conjugates bearing alkoxypropanols in the lipid portion of the molecule (11a-d). In addition, the long alkyl chain of alkoxyethyl ether lipid-AZT analogs was replaced with aromatic groups (11e-g), and the effect of this structural modification on activity is reported. The results of the biological tests indicate that analogs with a methyl group α to the phosphate moiety (11c,d) exhibit a marked degree of stereoselectivity with regard to their anti-HIV activity. Also, replacement of the long alkyl chain with aromatic groups in the oxyalkyl ether phospholipid-AZT conjugates leads to substantially more potent compounds (11e-g) with an anti-HIV activity comparable to that of AZT.