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4-Cyano-2-(trifluoromethyl)phenylhydrazine is a chemical compound characterized by the molecular formula C8H6F3N3. It presents as a yellow to brown solid that exhibits limited solubility in water but is readily soluble in organic solvents. 4-Cyano-2-(trifluoromethyl)phenylhydrazine is recognized for its utility in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds, and it has garnered interest for its potential antitumor and antiviral properties. However, it is also noted for its potential irritancy, necessitating careful handling with appropriate safety measures.

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  • 184163-56-2 Structure
  • Basic information

    1. Product Name: 4-Cyano-2-(trifluoromethyl)phenylhydrazine
    2. Synonyms: 4-Hydrazino-3-(trifluoromethyl)benzonitrile;4-Hydrazinyl-3-(trifluoromethyl)benzonitrile
    3. CAS NO:184163-56-2
    4. Molecular Formula: C8H6F3N3
    5. Molecular Weight: 201.15
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 184163-56-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-Cyano-2-(trifluoromethyl)phenylhydrazine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-Cyano-2-(trifluoromethyl)phenylhydrazine(184163-56-2)
    11. EPA Substance Registry System: 4-Cyano-2-(trifluoromethyl)phenylhydrazine(184163-56-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 184163-56-2(Hazardous Substances Data)

184163-56-2 Usage

Uses

Used in Organic Synthesis:
4-Cyano-2-(trifluoromethyl)phenylhydrazine is utilized as a reagent in organic synthesis for the preparation of a diverse range of pharmaceuticals. Its unique structure contributes to the development of new molecules with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 4-Cyano-2-(trifluoromethyl)phenylhydrazine is employed as a key intermediate in the synthesis of compounds designed to protect crops from pests and diseases, leveraging its reactivity to form new agrochemical entities.
Used in Pharmaceutical Research:
4-Cyano-2-(trifluoromethyl)phenylhydrazine is used as a precursor in the research and development of new pharmaceuticals, particularly those with antitumor and antiviral properties. Its potential biological activity makes it a valuable compound in the quest for novel treatments.
Used in Safety and Handling Protocols:
Due to its irritant nature, 4-Cyano-2-(trifluoromethyl)phenylhydrazine is also used as a case study in the development of safety protocols and handling guidelines for chemists and researchers to ensure safe laboratory practices when working with potentially hazardous substances.

Check Digit Verification of cas no

The CAS Registry Mumber 184163-56-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,1,6 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 184163-56:
(8*1)+(7*8)+(6*4)+(5*1)+(4*6)+(3*3)+(2*5)+(1*6)=142
142 % 10 = 2
So 184163-56-2 is a valid CAS Registry Number.

184163-56-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-hydrazinyl-3-(trifluoromethyl)benzonitrile

1.2 Other means of identification

Product number -
Other names PC7498

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:184163-56-2 SDS

184163-56-2Downstream Products

184163-56-2Relevant articles and documents

Dual-inhibitors of N-Myc and AURKA as potential therapy for neuroendocrine prostate cancer

Ban, Fuqiang,Cherkasov, Artem,Lallous, Nada,Leblanc, Eric,Lee, Joseph,Morin, Hélène,Singh, Kriti,Ton, Anh-Tien

, p. 1 - 19 (2020/11/11)

Resistance to androgen-receptor (AR) directed therapies is, among other factors, associated with Myc transcription factors that are involved in development and progression of many cancers. Overexpression of N-Myc protein in prostate cancer (PCa) leads to its transformation to advanced neuroendocrine prostate cancer (NEPC) that currently has no approved treatments. N-Myc has a short half-life but acts as an NEPC stimulator when it is stabilized by forming a protective complex with Aurora A kinase (AURKA). Therefore, dual-inhibition of N-Myc and AURKA would be an attractive therapeutic avenue for NEPC. Following our computer-aided drug discovery approach, compounds exhibiting potent N-Myc specific inhibition and strong anti-proliferative activity against several N-Myc driven cell lines, were identified. Thereafter, we have developed dual inhibitors of N-Myc and AURKA through structure-based drug design approach by merging our novel N-Myc specific chemical scaffolds with fragments of known AURKA inhibitors. Favorable binding modes of the designed compounds to both N-Myc and AURKA target sites have been predicted by docking. A promising lead compound, 70812, demonstrated low-micromolar potency against both N-Myc and AURKA in vitro assays and effectively suppressed NEPC cell growth.

Antithrombotic carboxylic acid amides

-

, (2008/06/13)

Carboxylic acid amides of formula having antithrombotic activity and a factor Xa-inhibiting activity. Exemplary are: 2-(5-amidino-2-hydroxy-phenyl)-N-[3-methyl-4-(2-tert-butoxycarbonylaminomethyl -benzimidazol-1-yl)-phenyl]-acetamide; 2-(5-amidino-2-hydro

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