184174-41-2

Upstream product

• 335119-90-9 acetic acid 4-oxo-6-trityloxymethyl-tetrahydro-pyran-2-yl methyl ester 
• 76-83-5 trityl chloride 
• 183952-48-9 Acetic acid (2R,6S)-6-hydroxymethyl-4-oxo-tetrahydro-pyran-2-ylmethyl ester 
• 183952-46-7 Acetic acid (8R,10S)-10-acetoxymethyl-3,3-dimethyl-1,5,9-trioxa-spiro[5.5]undec-8-ylmethyl ester 
• 183952-44-5 C₇H₈O₂C₅H₁₀O 
• 183952-45-6 ((8R,10S)-10-Hydroxymethyl-3,3-dimethyl-1,5,9-trioxa-spiro[5.5]undec-8-yl)-methanol 

Downstream Products

• 335119-97-6 (2-hydroxymethyl-6-trityloxymethyl-tetrahydro-pyran-4-ylidene)-acetic acid isopropyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of the C(10)-C(16) segment of the bryostatins

The C(10)-C(16) segment of the bryostatins has been synthesized (12 steps, 15% overall yield) and a cyanohydrin based strategy was developed for coupling with a C(1)-C(9) model.

Asymmetric synthesis of the northern half C1-C16 of the bryostatins

matrix presented Starting from 8-oxabicyclo[3.2.1]oct-6-en-3-one and racemic 2,2-dimethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one, the C1-C16 segment of the bryostatins has been synthesized in 30 steps and 9% overall yield (17 steps longest linear sequence). Fr