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184174-82-1

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184174-82-1 Usage

General Description

2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID ISOPROPYL ESTER is an organic compound with the molecular formula C13H17NO2S. It is an isopropyl ester derivative of the carboxylic acid 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid. This chemical is commonly used in the pharmaceutical industry as a precursor for the synthesis of various pharmaceutical drugs. It has applications in the development of drug candidates for the treatment of neurological disorders, such as schizophrenia and bipolar disorder, due to its ability to modulate neurotransmitter activity in the central nervous system. Additionally, it is also utilized as a building block in the synthesis of other organic compounds for various industrial and research applications.

Check Digit Verification of cas no

The CAS Registry Mumber 184174-82-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,1,7 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 184174-82:
(8*1)+(7*8)+(6*4)+(5*1)+(4*7)+(3*4)+(2*8)+(1*2)=151
151 % 10 = 1
So 184174-82-1 is a valid CAS Registry Number.

184174-82-1Relevant articles and documents

Design, Synthesis, and Structure-Activity Relationship of N-Aryl- N′-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy

Chen, Zhipeng,Zhang, Lina,Yang, Junjie,Zheng, Lu,Hu, Fanjie,Duan, Siqin,Nandakumar, Kutty Selva,Liu, Shuwen,Yin, Hang,Cheng, Kui

supporting information, p. 7371 - 7389 (2021/06/28)

The previous virtual screening of ten million compounds yielded two novel nonlipopeptide-like chemotypes as TLR2 agonists. Herein, we present the chemical optimization of our initial hit, 1-phenyl-3-(thiophen-2-yl)urea, which resulted in the identification of SMU-C80 (EC50 = 31.02 ± 1.01 nM) as a TLR2-specific agonist with a 370-fold improvement in bioactivity. Mechanistic studies revealed that SMU-C80, through TLR1/2, recruits the adaptor protein MyD88 and triggers the NF-κB pathway to release cytokines such as TNF-α and IL-1β from human, but not murine, cells. To the best of our knowledge, it is the first species-specific TLR1/2 agonist reported until now. Moreover, SMU-C80 increased the percentage of T, B, and NK cells ex vivo and activated the immune cells, which suppressed cancer cell growth in vitro. In summary, we obtained a highly efficient and specific human TLR1/2 agonist that acts through the MyD88 and NF-κB pathway, facilitating cytokine release and the simultaneous activation of immune cells that in turn affects the apoptosis of cancer cells.

Synthesis of urea analogues bearing N-alkyl-N’-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors

Chen, Zhipeng,Cen, Xiaohong,Yang, Junjie,Lin, Zhiman,Liu, Meihuan,Cheng, Kui

, p. 42 - 52 (2019/03/11)

Previous high throughput virtual screening of 10 million-compound and following cell based validation led to the discovery of a novel, nonlipopeptide-like chemotype ZINC 6662436, as toll-like receptor 2 (TLR2) agonists. In this report, compounds belonging

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

Perszyk, Riley,Katzman, Brooke M.,Kusumoto, Hirofumi,Kell, Steven A.,Epplin, Matthew P.,Tahirovic, Yesim A.,Moore, Rhonda L.,Menaldino, David,Burger, Pieter,Liotta, Dennis C.,Traynelis, Stephen F.

, (2018/08/28)

N-methyl-D-aspartate receptors (NMDARs) are an important receptor in the brain and have been implicated in multiple neurological disorders. Many non-selective NMDAR-targeting drugs are poorly tolerated, leading to efforts to target NMDAR subtyp

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