184221-86-1

Upstream product

• 3588-75-8 8-methoxy-naphthalen-1-ol 
• 569-42-6 1,8-dihydroxynaphthalene 
• 83-31-8 1,8-naphthosultone 

Downstream Products

• 1319715-16-6 C₂₀H₂₉BrO₂Si 
• 1319715-12-2 C₄₄H₅₆O₈Si 
• 1242319-39-6 C₄₂H₄₀O₈ 
• 82196-88-1 chrysomycin A 
• 80155-95-9 defucogilvocarcin V 
• 184221-88-3 4,4'-Bis-benzyloxy-5,5'-dimethoxy-[1,1']binaphthalenyl 
• 184221-87-2 4-Benzyloxy-1-bromo-5-methoxy-naphthalene 

Relevant academic research and scientific papers

SYNTHESIS OF THE POTENT IMMUNOSUPPRESSANT AGENTS DALESCONOL A AND B

This invention relates to compounds having the structure: wherein bonds α, β, γ, δ, ω, η, χ, ε, κ, and μ are each present or absent, and R1-R18 are various substituents described herein.

A concise approach to the dalesconol skeleton

A rapid approach to the skeleton of dalesconol A and B, unprecedented immunosuppressants, has been achieved through a convergent strategy featuring a carbocation-mediated dearomatization-cyclization and a following one-pot consecutive operation.

Total syntheses of dalesconol A and B

(Chemical equation Presented) (Chemical equation Presented) A polycyclic collapse: Use of a carefully designed acyclic intermediate participated in a cascade reaction that formed the entire core of the polyketide-derived dalesconols in a single flask (see scheme). A number of additional and carefully controlled synthetic operations completed an expeditious synthesis of both of these highly bioactive natural products as well as structural congenors.