18423-40-0

Basic information

• Product Name: dGTP hydrate sodium salt
• Synonyms: 2μ-Deoxyguanosine 5μ-triphosphate hydrate sodium salt;dGTP hydrate sodium salt
• CAS NO: 18423-40-0
• Molecular Formula: C10H13N5Na3O13P3
• Molecular Weight: 573.126513
• EINECS: 300-026-5
• Mol File: 18423-40-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: dGTP hydrate sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: dGTP hydrate sodium salt(18423-40-0)
• EPA Substance Registry System: dGTP hydrate sodium salt(18423-40-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36
• WGK Germany: 3
• Hazardous Substances Data: 18423-40-0(Hazardous Substances Data)

Usage

Uses

Used in Molecular Biology Research:
dGTP hydrate sodium salt is used as a substrate for DNA polymerase and reverse transcriptase enzymes in molecular biology research. It is essential for studying the distribution, specificity, and kinetics of various nucleoside triphosphatases (NTPases) and ribonucleotide reductases, which are involved in the synthesis and metabolism of nucleotides.
Used in Diagnostic Applications:
In the field of diagnostics, dGTP hydrate sodium salt is utilized as a component in the formulation of DNA sequencing and polymerase chain reaction (PCR) kits. It is crucial for the accurate and efficient amplification of DNA fragments and the determination of DNA sequences, which are vital for disease diagnosis, genetic testing, and forensic analysis.
Used in Drug Development:
dGTP hydrate sodium salt is also employed in the development of novel drugs targeting DNA polymerases and reverse transcriptases, which are involved in the replication of DNA and RNA, respectively. These enzymes are often the targets of antiviral and anticancer drugs, as they play a critical role in the life cycle of viruses and cancer cells.
Used in Gene Synthesis and Manipulation:
In the field of genetic engineering, dGTP hydrate sodium salt is used as a building block for the synthesis of DNA fragments and the manipulation of genes. It is an essential component in various DNA synthesis techniques, such as site-directed mutagenesis and gene cloning, which are used to create recombinant DNA molecules and genetically modified organisms for research and commercial purposes.
Used in Biochemical Education:
dGTP hydrate sodium salt is also utilized as a teaching aid in biochemical education, where it helps students understand the fundamental processes of DNA replication, transcription, and translation. It is often used in laboratory exercises and demonstrations to illustrate the role of nucleotides in genetic information transfer and expression.