184241-44-9

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Basic information

Product Name: 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE
Synonyms: 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE;NBI 27914 HYDROCHLORIDE;5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediaminehydrochloride;NBI27914HCl
CAS NO:184241-44-9
Molecular Formula: C18H21Cl5N4
Molecular Weight: 470.65
EINECS: N/A
Product Categories: CRF receptor and related
Mol File: 184241-44-9.mol
Article Data: 0

Chemical Properties

Melting Point: N/A
Boiling Point: 483.7°Cat760mmHg
Flash Point: 246.3°C
Appearance: white/solid
Density: 1.417g/cm³
Refractive Index: N/A
Storage Temp.: 2-8°C
Solubility: DMSO: 16 mg/mL at 60 °C, soluble
CAS DataBase Reference: 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE(CAS DataBase Reference)
NIST Chemistry Reference: 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE(184241-44-9)
EPA Substance Registry System: 5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE(184241-44-9)

Safety Data

Hazard Codes: Xi
Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 184241-44-9(Hazardous Substances Data)

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Cas No: 184241-44-9
USD $ 139.0-210.0 / Kilogram
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Zhuozhou Wenxi import and Export Co., Ltd
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NBI-27914
Cas No: 184241-44-9
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BOC Sciences
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5-CHLORO-N-(CYCLOPROPYLMETHYL)-2-METHYL-N-PROPYL-N'-(2,4,6-TRICHLOROPHENYL)-4,6-PYRIMIDINEDIAMINE HYDROCHLORIDE
Cas No: 184241-44-9
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ZHEJIANG JIUZHOU CHEM CO.,LTD
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NBI 27914 hydrochloride;5-Chloro-N-(cyclopropylMethyl)-2-Methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyriMidinediaMinehydrochloride
Cas No: 184241-44-9
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Wuxi Morality Chemical Co., Ltd
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184241-44-9 Usage

Uses

NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:to study its effects on steroidogenic gene expression in GD15 mouse testis to study its effects on amyloid β production to study its effects on neurogenic activity of neural stem cells in the adult hippocampus

Biological Activity

Selective, non-peptide corticotropin-releasing factor 1 (CRF 1 ) receptor antagonist (K i = 1.7 nM); has no activity at CRF 2 receptors. Blocks behavioral seizures in vivo .

Biochem/physiol Actions

NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 184241-44-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,2,4 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 184241-44:
(8*1)+(7*8)+(6*4)+(5*2)+(4*4)+(3*1)+(2*4)+(1*4)=129
129 % 10 = 9
So 184241-44-9 is a valid CAS Registry Number.

184241-44-9 Well-known Company Product Price

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(Code)Product description
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Sigma
(N3911) NBI 27914 ≥98% (HPLC)
184241-44-9
N3911-10MG
1,556.10CNY
Detail

Sigma
(N3911) NBI 27914 ≥98% (HPLC)
184241-44-9
N3911-50MG
6,873.75CNY
Detail

184241-44-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name	5-chloro-4-N-(cyclopropylmethyl)-2-methyl-4-N-propyl-6-N-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine

1.2 Other means of identification

Product number	-
Other names	Lopac-N-3911

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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