184294-17-5Relevant academic research and scientific papers
Alkylation of sterically hindered 1,3-diketones under phase-transfer conditions
Zanlna,Shergina,Sokolov,Shvartsberg
, p. 2389 - 2392 (1996)
Sterically hindered 1,3-diketones react selectively with propargyl and allyl bromides under conditions of phase transfer catalysis to give C-alkylated products, whereas reactions with butyl and benzyl chlorides yield mixtures of C- and O-isomers. An increase in the size of the substituents present in the initial 1.3-diketone hampers introduction of the second propargyl group. The propargyl-substittitcd 1,3-diketones undergo cyclization under the alkylation conditions to give substituted furans.
