18435-67-1

Usage

Uses

Used in Cardiovascular Applications:
Molsidomine is used as a vasodilator for the treatment of angina pectoris and heart failure. It functions by releasing nitric oxide, which relaxes blood vessels and enhances blood flow to the heart, thereby reducing the workload on the heart and improving oxygen delivery to the myocardium.
Used in Erectile Dysfunction Treatment:
Molsidomine is being studied for its potential use in treating erectile dysfunction. As a nitric oxide donor, it may help improve blood flow to the penile tissues, aiding in achieving and maintaining an erection.
Used in Pulmonary Hypertension Treatment:
Molsidomine has shown promising results in improving exercise capacity and quality of life in patients with pulmonary hypertension. It is being investigated for its potential to treat this condition by enhancing blood flow and reducing the workload on the heart.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Molsidomine is utilized as an active ingredient in the development of drugs targeting cardiovascular diseases, erectile dysfunction, and pulmonary hypertension. Its NO donor properties make it a valuable compound for creating medications that can improve blood flow and reduce the strain on the heart.

Upstream product

• 186581-53-3 diazomethane 
• 4376-18-5 Monomethyl phthalate 
• 4397-55-1 phthalic monoacid monomethyl ester chloride 

Downstream Products

• 31582-47-5 2-chloroacetyl-benzoic acid methyl ester 
• 5693-27-6 isochroman-1,4-dione 
• 117788-11-1 C₂₀H₁₆O₆ 
• 88387-92-2 (1R,9R,10R)-10-(2,6-Dichloro-phenyl)-1-methoxy-11,12-dioxa-tricyclo[7.2.1.0^2,7]dodeca-2,4,6-trien-8-one 
• 88387-92-2 (1R,9R,10S)-10-(2,6-Dichloro-phenyl)-1-methoxy-11,12-dioxa-tricyclo[7.2.1.0^2,7]dodeca-2,4,6-trien-8-one 
• 88387-95-5 (1S,9S,10S)-1-Methoxy-10-(4-methoxy-phenyl)-11,12-dioxa-tricyclo[7.2.1.0^2,7]dodeca-2,4,6-trien-8-one 
• 88387-95-5 (1S,9S,10R)-1-Methoxy-10-(4-methoxy-phenyl)-11,12-dioxa-tricyclo[7.2.1.0^2,7]dodeca-2,4,6-trien-8-one 
• 142822-76-2 C₂₇H₂₀ClNO₆S 
• 142822-77-3 C₄₇H₃₆ClNO₁₂S 
• 142846-41-1 C₅₇H₄₄ClNO₁₅S 

Relevant academic research and scientific papers

Regio- and Diastereoselective Dimerization of Diazo Carbonyls: A Cooperative Catalytic Approach to Complex Scaffolds with Four Contiguous Stereocenters

Starting from readily available o-diazoacyl-substituted arene carboxylates, scaffolds with the 5,9-epoxycyclohepta[b]pyran-2(3H)-one core were obtained by cooperative RhII, Lewis and Br?nsted acid catalysis. Four new bonds, three functional gro

A Rh(II)-catalyzed cycloaddition approach toward the synthesis of komaroviquinone

Using a rhodium(II)-catalyzed cyclization/cycloaddition sequence as the key reaction step, the icetexane core of komaroviquinone was constructed by an intramolecular dipolar-cycloaddition of a carbonyl ylide dipole across a tethered π-bond. The ylide was arrived at by cyclization of a rhodium carbenoid intermediate onto a proximal ester group. Efforts toward the preparation of the required precursor for elaboration to the natural product are discussed.

Efficient construction of the oxatricyclo[6.3.1.00,0]dodecane core of komaroviquinone using a cyclization/cycloaddition cascade of a rhodium carbenoid intermediate

(Chemical Equation Presented) The rhodium(II)-catalyzed cyclization/cycloaddition cascade of a o-carbomethoxyaryl diazo dione is described as a potential route to the oxatricyclo[6.3.1.00.0]dodecane substructure of the icetexane diterpene komar

Ruthenium(II) porphyrin catalyzed tandem carbonyl ylide formation and 1,3-dipolar cycloaddition reactions of α-diazo ketones

equation presented The ruthenium porphyrin-catalyzed reactions of diazo ketones with π-unsaturated compounds via carbonyl ylide formation/cycloaddition cascade exhibit product yields and selectivities comparable to the analogous reactions with dirhodium c

SYNTHESES OF 4-HYDROXYMETHYL-1(2H)-PHTALAZINONE AND ITS ANALOGS.

4-Hydroxymethyl-1(2H)-phthalazinone (2) was preferably prepared by reduction of 4-ethoxycarbonyl-1(2H)-phtalazinone with NaBH4 in EtOH in good yield.The synthetic method was applicable for the preparation of 7-ethoxycarbonyl-4-hydroxymethyl-1(2H)-phthalazinone and its 2-phenyl derivative, where the regioselective reduction of the ester at the position 4 was possible, leaving the ester at the position 7 intact.The Grignard reaction of 4-ethoxycarbonyl-1(2H)-phthalazinone was also described.