18436-01-6Relevant articles and documents
Synthesis, reactions and DNA damaging abilities of 10-membered enediyne-sulfone and related compounds
Suzuki, Ichiro,Shigenaga, Akira,Manabe, Atsuo,Nemoto, Hisao,Shibuya, Masayuki
, p. 5691 - 5704 (2007/10/03)
The synthesis and Myers-Saito type cycloaromatization reactions of 10-membered enediynes containing a sulfone or a sulfoxide moiety are described. These enediynes cycloaromatized smoothly under physiological conditions to generate bioactive α,3-didehydrotoluene biradicals, that showed potent DNA damaging abilities. Further, in the presence of a nucleophile such as amine or sulfide, cycloaromatization did not occur following the radical reaction pathway but ionically induced cycloaromatization took place.