184363-66-4Relevant articles and documents
A method for synthesis of acylated oxazolidone
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Paragraph 0028; 0029; 0030; 0040; 0041; 0042, (2019/01/08)
The invention discloses a method for synthesis of acylated oxazolidone. Synthesis method of the invention, comprising the following steps: in the non-protic organic solvent, the compound III and under the action of an acid, the compound I with compound II carries out amidation reaction, to obtain compound IV. The method of the invention can be conducted under mild conditions, high yield, high purity, and is suitable for industrial production requirements.
Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts
Perry, Matthew A.,Trinidad, Jonathan V.,Rychnovsky, Scott D.
supporting information, p. 472 - 475 (2013/04/11)
A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.
Development of a scalable process for 1-β-methyl azetidinone: A carbapenem key intermediate
Tewari, Neera,Nizar, Hashim,Rai, Bishwa Prakash,Mane, Avinash,Prasad, Mohan
, p. 827 - 829 (2012/12/26)
An optimized process for the stereoselective synthesis of 1-β-methyl carbapenem key intermediate (3S,4S)-[(R)-1′-((tert-butyldimethylsilyl)oxy) ethyl]-4-[(R)-1-carboxyethyl]-2-azetidinone (1) and (3R,4R)-4-acetoxy-3-[(R)- 1′-((tert-butyldimethylsilyl)oxy)ethyl]-2-azetidinone has been developed employing commercially available chiral 4-phenyl-2-oxazolidinone. This method provides an efficient and cost-effective process with improved selectivity and higher yield.