184416-84-0

Basic information

• Product Name: 2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID
• Synonyms: 2,3-DICHLOROISONICOTINIC ACID;2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID;2,3-dichloroisonicotic acid;2,3-Dichloropyridine-4-carboxylic acid, 4-Carboxy-2,3-dichloropyridine;2,3- twochlorineisonicotinic acid
• CAS NO: 184416-84-0
• Molecular Formula: C₆H₃Cl₂NO₂
• Molecular Weight: 192
• EINECS: 1592732-453-0
• Product Categories: Pyridines
• Mol File: 184416-84-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 187°
• Boiling Point: 413.576 °C at 760 mmHg
• Flash Point: 203.924 °C
• Appearance: /Solid
• Density: 1.612 g/cm³
• Vapor Pressure: 1.4E-07mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.46±0.28(Predicted)
• CAS DataBase Reference: 2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID(184416-84-0)
• EPA Substance Registry System: 2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID(184416-84-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 184416-84-0(Hazardous Substances Data)

Usage

General Description

2,3-Dichloropyridine-4-carboxylic acid is a type of organic compound known for its significant role in pharmaceuticals, pesticides, and dyestuffs. Its molecular formula is C6H3Cl2NO2, illustrating that it contains elements such as carbon, hydrogen, chlorine, nitrogen, and oxygen. This chemical compound, also called dichloropyridine carboxylic acid, is often used as an intermediate in organic synthesis. This substance is considered harmful if swallowed, according to hazard classifications, and it may cause skin and eye irritation. Therefore, proper safety precautions must be taken when handling it.

InChI:InChI=1/C6H3Cl2NO2/c7-4-3(6(10)11)1-2-9-5(4)8/h1-2H,(H,10,11)

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 124-38-9 carbon dioxide 
• 184416-82-8 2,3-dichloroisonicotinonitrile 

Downstream Products

• 1222184-71-5 3-((4-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid 
• 1222185-17-2 dimethyl 3-((4-methoxybenzyl)amino)pyridine-2,4-dicarboxylate 

Relevant articles and documents

8-ANILIN0IMIDAZ0PYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS

The invention relates to imidazopyridines of formula I with anti -cancer and/or anti- inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperprolif erative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (Formula I)

Strategies for the selective functionalization of dichloropyridines at various sites

Whereas 2,3-dichloropyridine and 2,5-dichloro-4-(lithiooxy)-pyridine undergo deprotonation exclusively at the 4- and 2-positions, respectively, optional site selectivity can be implemented with 2,5- and 3,4-dichloropyridine (which are attacked, depending on the choice of the reagents, at either the 4- or 6- and either the 2- and 5-positions, respectively). Upon treatment with lithium diisopropylamide, 2,4-dichloro-3-iodopyridine, 3,5-dichloro-4-bromopyridine and 2,6-dichloro-3-iodopyridine afford 5-, 2- and 4-lithiated intermediates, but the latter isomerize instantaneously to species in which lithium and iodine have swapped places, the driving force being the low basicity of C-Li bonds when flanked by two neighboring halogens.