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Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate is a complex organic compound derived from tert-butyl carbamate and featuring a tert-butyldimethylsilyl group. It serves as a crucial protecting group for alcohols in organic reactions, particularly in the synthesis of intricate molecules. The tert-butyldimethylsilyl group endows the alcohol functional group with stability and protection, enabling selective reactions without altering the alcohol moiety. Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate is an indispensable tool in organic chemistry for the manipulation and functionalization of alcohol groups in complex molecule synthesis.

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  • Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate

    Cas No: 184429-84-3

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  • 184429-84-3 Structure
  • Basic information

    1. Product Name: Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate
    2. Synonyms: Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate;tert-Butyl (3-((tert-butyldimethylsilyl)oxy)-2-oxopropyl)carbamate
    3. CAS NO:184429-84-3
    4. Molecular Formula: C14H29NO4Si
    5. Molecular Weight: 303.46986
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 184429-84-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 347.5±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 0.975±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 10.85±0.46(Predicted)
    10. CAS DataBase Reference: Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate(CAS DataBase Reference)
    11. NIST Chemistry Reference: Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate(184429-84-3)
    12. EPA Substance Registry System: Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate(184429-84-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 184429-84-3(Hazardous Substances Data)

184429-84-3 Usage

Uses

Used in Organic Synthesis:
Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate is used as a protecting group for alcohols in organic synthesis to facilitate selective reactions without affecting the alcohol moiety.
Used in Chemical Research:
In the field of chemical research, Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate is utilized for the manipulation and functionalization of alcohol groups in complex molecule synthesis, providing stability and protection to the alcohol functional group.
Used in Pharmaceutical Industry:
Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate is used as a key intermediate in the synthesis of pharmaceutical compounds, aiding in the development of new drugs by protecting alcohol groups during the synthesis process.
Used in Material Science:
In material science, Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate is employed in the synthesis of advanced materials, where the protection of alcohol groups is essential for creating complex molecular structures with specific properties.

Check Digit Verification of cas no

The CAS Registry Mumber 184429-84-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,4,2 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 184429-84:
(8*1)+(7*8)+(6*4)+(5*4)+(4*2)+(3*9)+(2*8)+(1*4)=163
163 % 10 = 3
So 184429-84-3 is a valid CAS Registry Number.

184429-84-3Downstream Products

184429-84-3Relevant articles and documents

Allylamine derivative as well as preparation method and application thereof

-

, (2021/06/02)

The invention relates to an allylamine derivative as well as a preparation method and application thereof, and in particular, relates to a compound represented by a formula I, or a stereoisomer, a tautomer, a polymorphic substance, a solvate, an N-oxide, an isotope labeled compound, a metabolite, a prodrug or ester thereof, or a pharmaceutically acceptable salt thereof. The compound has a higher inhibitory activity against vascular adhesion protein 1/semicarbazide sensitive amine oxidase, a good selectivity against monoamine oxidase and diamine oxidase; and additionally, in some embodiments, the mixture has a high in vivo bioavailability as well as safety.

Preparation and application of aminourea sensitive amine oxidase inhibitor

-

, (2021/07/24)

The invention provides preparation and application of an aminourea sensitive amine oxidase inhibitor. Specifically, the invention discloses a compound as shown in a formula I, or a stereoisomer, raceme or pharmaceutically acceptable salt thereof. The invention also discloses the compound capable of inhibiting the aminourea sensitive amine oxidase.

VASCULAR ADHESION PROTEIN-1 (VAP-1) MODULATORS AND THERAPEUTIC USES THEREOF

-

, (2020/01/24)

Disclosed herein are small molecule Vascular Adhesion Protein- 1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.

FLUOROALLYLAMINE DERIVATIVE AND USE THEREOF

-

, (2020/03/17)

The present invention relates to a fluoroallylamine derivative and use thereof. In particular, the present invention relates to a compound as shown in Formula I, a prodrug, an isomer, an isotope-labeled compound, a solvate or a pharmaceutically acceptable salt thereof, which has VAP-1/SSAO inhibitory activity, and can be used for treating a disease associated with VAP-1/SSAO overactivity.

SSAO INHIBITOR

-

, (2020/04/02)

The present invention provides an SSAO inhibitor and an application thereof in preparing a drug for treating a disease related to SSAO. In particular, the present invention provides a compound shown in formula (IV) and a pharmaceutically acceptable salt thereof.

Halogenated allyl amine type SSAO/VAP-1 inhibitor and application thereof

-

, (2019/06/08)

The invention belongs to the technical field of medicine, and particularly relates to a halogenated allyl amine type compound shown as a formula I, medically acceptable salt, ester or stereo isomers thereof, wherein R1, R2, R3, R4, R5, R6, L1, Cy1, R7 and p are defined in description. The invention also relates to a medicine preparation containing the compounds, a medicine composition containing the compounds, and application of the compounds to prevention and/or treatment on diseases relevant to SSAO/VAP 1 protein or diseases caused by SSAO/VAP 1 protein mediating. The formula I is shown in the description.

SSAO INHIBITORS AND USES THEREOF

-

, (2020/01/08)

Described herein are compounds that are semicarbazide-sensitive amine oxidase (SSAO) inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in treating or preventing a liver disease or condition.

SUBSTITUTED 3-HALOALLYLAMINE INHIBITORS OF SSAO AND USES THEREOF

-

, (2013/11/19)

The present invention is related to the preparation and pharmaceutical use of substituted 3-haloallylamine derivatives as SSAO/VAP-1 inhibitors having the structure of Formula (I), as defined in the specification. The invention also relates to methods of using compounds of Formula (I), or pharmaceutically acceptable salt or derivatives thereof, for the treatment of a variety of indications, e.g., inflammatory diseases, ocular diseases, fibrotic diseases, diabetes-induced diseases and cancer.

Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine β-hydroxylase

Beliaev, Alexandre,Learmonth, David A.,Soares-Da-Silva, Patricio

, p. 1191 - 1197 (2007/10/03)

A novel series of dopamine β-hydroxylase (DBH) inhibitors was designed and synthesized incorporating modifications to the core structure of nepicastat 3, with the principal aim of discovering potent DBH inhibitors exerting minimal effects on dopamine (DA) and noradrenaline (NA) levels in the central nervous system. This study resulted in the identification of a potent, peripherally selective DBH inhibitor, (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3- dihydroimidazole-2-thione hydrochloride 54 (BIA 5-453). In experiments in mice and rats at Tmax (9 h after administration), 54 reduced NA levels in a dose-dependent manner in both the left atrium and the left ventricle, with the maximal inhibitory effect attained at a dose of 100 mg/kg. In contrast to that found in the heart, 54 failed to affect NA tissue levels in the brain. Compound 54 is thus presented as a candidate for clinical evaluation for the treatment of chronic heart failure and hypertension.

5-hydroxypentane-2,3-dione and 3-amino-1-hydroxypropan-2-one, putative precursors of vitamin B6

Wolf, Eckardt,Kennedy, Isaac A.,Himmeldirk, Klaus,Spenser, Ian D.

, p. 942 - 948 (2007/10/03)

New synthesis are described of 5-hydroxypentane-2,3-dione (7) (i.e., laurencione (7 ? 8)) and of 3-amino-1-hydroxypropan-2-one (3-amino-1- hydroxyacetone) (5) hydrochloride, putative precursors of the C5 unit, C- 2',2,3,4,4', and of the C3N unit, N-1,C-6,5,5', respectively, of pyridoxine (6). The condensation of hydroxypentane dione (i.e., laurencione) and aminohydroxypropanone forms a vitamin B, pyridoxine. The two compounds incorporated structural modifications on the formation mechanism of vitamin B. These compounds were considered as putative precursors of the C5 unit and the C3N unit of pyridoxine.

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