18443-20-4

Basic information

• Product Name: 7-chloro-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole
• Synonyms: 7-Chloro-1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine
• CAS NO: 18443-20-4
• Molecular Formula: C₁₁H₁₁ClN₂
• Molecular Weight: 206.6714
• Mol File: 18443-20-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 396.4°C at 760 mmHg
• Flash Point: 193.6°C
• Density: 1.38g/cm³
• Vapor Pressure: 3.9E-06mmHg at 25°C
• Refractive Index: 1.694
• CAS DataBase Reference: 7-chloro-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole(18443-20-4)
• EPA Substance Registry System: 7-chloro-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole(18443-20-4)

Safety Data

• Hazardous Substances Data: 18443-20-4(Hazardous Substances Data)

Upstream product

• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 111-30-8 Glutaraldehyde 
• 33784-44-0 1-(4-chloro-2-nitrophenyl)piperidine 

Relevant articles and documents

Synthesis of Quinone Derivatives of Benzannelated Heterocycles with Bridgehead Nitrogen

Abstract: A facile synthesis of para-quinones derived from fused benzimidazoles with a bridgehead nitrogen atom was developed. The heterocyclic quinone core formed as a result of reductive cyclization of ortho-nitroarenes containing alicyclic and aromatic azaheterocycles. Functionalization of 1,2,3,4-tetrahydro- and pyrido[1,2-a]benzimidazoles via SEAr, condensation, and reduction reactions allowed synthesis of amino derivatives which were oxidized with KNO3 in H2SO4 to obtain novel heterocyclic quinones.

Formic acid as a sustainable and complementary reductant: An approach to fused benzimidazoles by molecular iodine-catalyzed reductive redox cyclization of: O -nitro- t -anilines

Molecular iodine was found to be an excellent catalyst for reductive redox cyclization of o-nitro-t-anilines 1 into fused tricyclic or 1,2-disubtituted benzimidazoles 2. A range of functional groups such as halides (F, Cl, Br), methoxy, ester, trifluoromethyl, cyano, pyridine and even nitro groups were tolerated using formic acid as a clean, safe, user-friendly and complementary reductant. When iodine was used in a stoichiometric amount (50 mol%), the methodology allowed the direct synthesis of benzimidazole hydroiodides 2·HI in high yields by simple precipitation from the reaction mixture.

Methine dyes

The invention relates to a new class of pyrrolobenzimidazole, benzimidazoloisoquinoline and dipyrodinobenzodiimidazole in cyanine sensitizing dyes derived therefrom and their use in silver halide emulsions, and to methods for preparation of such new dyes.