184473-69-6Relevant academic research and scientific papers
Reaction of indole-2,3-dicarboxylic anhydride with (3-bromo-4-pyridyl)triisopropoxytitanium: Synthesis of ellipticine
Miki, Yasuyoshi,Tada, Yoshitaka,Yanase, Norihide,Hachiken, Hiroko,Matsushita, Ko-Ichi
, p. 7753 - 7754 (1996)
N-Benzylindole-2,3-dicarboxylic anhydride (1) was reacted with (3-bromo-4-pyridyl)triisopropoxytitanium to give 2-(3-bromoisonicotinoyl)indole-3-carboxylic acid (2) as the sole product in high yield, which could be converted to ellipticine in six steps.
Synthesis of ellipticine by reaction of 1-(4-methoxybenzyl)indole-2,3-dicarboxylic anhydride with (3-bromo-4-pyridyl)-triisopropoxytitanium
Miki, Yasuyoshi,Hachiken, Hiroko,Yanase, Norihide
, p. 2213 - 2216 (2007/10/03)
The synthesis of ellipticine by the reaction of 1-(4-methoxybenzyl)indole-2,3-dicarboxylic anhydride with (3-bromo-4-pyridyl)-triisopropoxytitanium was reported. The reaction involved the deprotection of the 1-(4-methoxybenzyl) group of the 2-acylindole-3-carboxylic acid by treatment with perchloric acid in acetic acid to afford 2-(3-bromoisonicotinoyl)indole, which was then converted to ellipticine. The effect of different reagents and conditions on the reaction was observed and infrared spectrometry was performed on the products.
Reaction of l-benzylindole-2,3-dicarboxylic anhydride with 3-bromo-4-lithiopyridine: Formal synthesis of ellipticine
Miki, Yasuyoshi,Tada, Yoshitaka,Matsushita, Ko-Ichi
, p. 1593 - 1597 (2007/10/03)
Reaction of l-benzylindole-2,3-dicarboxylic anhydride with 3-bromo-4-lithiopyridine gave 2-(3-bromoisonicotinoyl)indole-3-carboxylic acid as the sole product. The indole-3-carboxylic acid could be converted to 6-benzylellipticine quinone in five steps.
