184535-50-0Relevant academic research and scientific papers
An efficient method for the synthesis of N,N′-dimethyl-1,2-diamines
Tye, Heather,Eldred, Colin,Wills, Martin
, p. 155 - 158 (2007/10/03)
A simple method for the preparation of N,N′-dimethyl-1,2-diamines is described. The method requires the dimethylation of a diazaphospholidine oxide followed by acid-catalysed hydrolysis.
The asymmetric synthesis of α-substituted α-methyl and α-phenyl phosphonic acids: Design, carbanion geometry, reactivity and preparative aspects of chiral alkyl bicyclic phosphonamides
Bennani, Youssef L.,Hanessian, Stephen
, p. 13837 - 13866 (2007/10/03)
The design, preparation, structural and spectroscopic analyses of topologically unique and enantiomerically pure alkyl phosphonamides are described. In the case of α-ethyl and α-benzyl phosphonamides, the geometry of both the secondary and tertiary carbanions was determined to be planar through deprotonation/deuteration/alkylation experiments. Stereoselective alkylations of such systems proceeded in good yields and with high diastereoselectivities. The resulting α,α-alkylated phosphonamides were hydrolyzed to give the corresponding α,α-alkyl phosphonic acids with high degrees of enantiomeric purity.
