184575-16-4Relevant academic research and scientific papers
Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs
Genin,Poel,Yagi,Biles,Althaus,Keiser,Kopta,Friis,Reusser,Adams,Olmsted,Voorman,Thomas,Romero
, p. 5267 - 5275 (2007/10/03)
The major route of metabolism of the bis(heteroaryl)piperazine (BHAP) class of reverse transcriptase inhibitors (RTIs), atevirdine and delavirdine, is via oxidative N-dealkylation of the 3-ethyl- or 3-isopropylamino substituent on the pyridine ring. This
