18461-28-4

Basic information

• Product Name: 3-(2-FURYL)-1-(3-PYRIDINYL)-2-PROPEN-1-ONE
• Synonyms: 3-(2-FURYL)-1-(3-PYRIDINYL)-2-PROPEN-1-ONE;(2E)-3-(furan-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one
• CAS NO: 18461-28-4
• Molecular Formula: C12H9NO2
• Molecular Weight: 199.21
• Mol File: 18461-28-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2-FURYL)-1-(3-PYRIDINYL)-2-PROPEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-FURYL)-1-(3-PYRIDINYL)-2-PROPEN-1-ONE(18461-28-4)
• EPA Substance Registry System: 3-(2-FURYL)-1-(3-PYRIDINYL)-2-PROPEN-1-ONE(18461-28-4)

Safety Data

• Hazardous Substances Data: 18461-28-4(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 1358067-70-5 4-(2-furyl)-6-thioxo-1,6-dihydro-2,3'-bipyridine-5-carbonitrile 
• 1649454-99-8 [3-amino-4-(2-furyl)-6-(pyridin-3-yl)thieno[2,3-b]pyridin-2-yl](4-chlorophenyl)methanone 
• 1649454-98-7 [3-amino-4-(2-furyl)-6-(pyridin-3-yl)thieno[2,3-b]pyridin-2-yl](phenyl)methanone 
• 1649454-90-9 4-(2-furyl)-6-[(2-oxo-2-phenylethyl)thio]-2,3'-bipyridine-5-carbonitrile 

Relevant articles and documents

Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities

For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C15 showed the most significant dual COX/5-LOX inhibitory activity.

NOVEL PROPENONE DERIVATIVES CONTAINING AROMATIC RINGS, A MAUFACTURING PROCESS THEREOF AND A COMPOSITION CONTAINING THE SAME USING AS AN ANTIINFLAMMATORY AGENT

The present invention is related to novel propenone derivatives containing aromatic ring, a manufacturing process thereof and a composition containing the same using as an anti? inflammatory agent. The compound of the present invention show potent anti-inflammatory activity confirmed by various experiments for example, the inhibition test of COX and 5-LOX enzyme activity, the inhibition test of LTC reproduction and NO production, MTT assay test, the inhibition test on the iNOS and COX-2 protein expression and PGE reproduction using RAW 264.7 macrophage etc. Accordingly, present compounds can be useful in treating and preventing various inflammatory.