184637-48-7

Basic information

• Product Name: N-BOC-3-Aminopiperidine
• Synonyms: TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE;N-1-BOC-3-AMINOPIPERIDINE;N-BOC-3-AMINOPIPERIDINE;DL-3-AMINO-1-N-BOC-PIPERIDINE;(+/-)-1-BOC-3-AMINO-PIPERIDINE;1-BOC-3-AMINOPIPERIDINE;1-BOC-3-AMINOPIPERIDINE CITRIC ACID SALT;1-N-BOC-3-AMINOPIPERIDINE
• CAS NO: 184637-48-7
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Product Categories: Pharmaceutical Intermediates;AMINOACID;pharmacetical;Piperidine;Chiral Reagent;Piperidines
• Mol File: 184637-48-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 181-182°C
• Boiling Point: 277.3 °C at 760 mmHg
• Flash Point: 121.5 °C
• Appearance: /
• Density: 1.02
• Vapor Pressure: 0.00456mmHg at 25°C
• Refractive Index: 1.4710-1.4750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.35±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: N-BOC-3-Aminopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-3-Aminopiperidine(184637-48-7)
• EPA Substance Registry System: N-BOC-3-Aminopiperidine(184637-48-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-51
• Safety Statements: 26-39-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 184637-48-7(Hazardous Substances Data)

Usage

Uses

3-Amino-1-Boc-piperidine is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/p+1/t8-/m1/s1

Upstream product

• 478828-62-5 (1-benzylpiperidin-3-yl)carbamic acid tert-butyl ester 
• 397246-12-7 (1,5-dihydroxypent-2-yl)carbamic acid tert-butyl ester 
• 861658-15-3 1,5-dimethyl 2-[(t-butoxycarbonyl)amino]pentanedioate 
• 617-65-2 Glutamic acid 
• 6525-53-7 glutamic acid dimethyl ether 
• 462-08-8 pyridin-3-ylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 334618-23-4 (R)-piperidin-3-ylamine hydrochloride 
• 635722-83-7 9H-fluoren-9-ylmethyl 3-t-butoxycarbonylaminopiperidine-1-carboxylate 
• 406213-47-6 3-t-butoxycarbonylaminopiperidin-1-carboxylic acid benzyl ester 
• 56700-70-0 3-(tert-butoxycarbonylamino)pyridine 
• 54012-73-6 3-aminopiperidine 

Downstream Products

• 454710-78-2 1-(2-phenyl-2-oxo-ethyl)-3-methyl-7-(3-methyl-2-buten-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine 
• 1043905-04-9 C₂₀H₃₁N₇O₄ 
• 1043905-13-0 C₁₅H₂₂N₆O₂ 
• 1270015-10-5 N-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-N-methyl-2-(phenylamino)acetamide 
• 1270019-60-7 tert-butyl methyl(1-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)carbamate 
• 1270019-61-8 N-methyl-2-(phenylamino)-N-(1-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)acetamide 
• 1270954-31-8 (Z)-1-(1-(7H-pyrrolo[2.3-d]pyrimidin-4-yl)piperidin-3-yl)-3-(2-chlorophenyl)-2-cyanoguanidine 
• 1270954-37-4 phenyl N'-cyano-N-(1-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)carbamimidate 
• 1270954-38-5 1-(2-chlorophenyl)-2-cyano-3-(1-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)guanidine 
• 1270014-35-1 N-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-2-(methyl(phenyl)amino)acetamide 
• 1270019-57-2 1-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine 
• 1270019-58-3 2-chloro-N-(1-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)acetamide 
• 1270019-59-4 2-(methyl(phenyl)amino)-N-(1-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)acetamide 
• 1270014-16-8 N-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-2-(phenylamino)acetamide 

Relevant articles and documents

Synthetic process of anti-hyperglycemic drug intermediate R-3-amino-piperidine dihydrochloride

The invention relates to a synthetic process of an anti-hyperglycemic drug intermediate R-3-amino-piperidine dihydrochloride. The synthetic process comprises the steps: using inexpensive L-glutamic acid as a starting material, and performing esterification, amino protection, reduction, hydroxyl protection, substitution, cyclization and removal of protecting groups for amino groups so as to obtainthe R-3-amino-piperidine dihydrochloride. Compared with the prior art, the synthetic process has cheap and easily available raw materials, good selectivity, good atomic economy, high total yield and mild reaction conditions, and is suitable for industrial production.

MANUFACTURING METHOD FOR A PIPERIDINE-3-YLCARBAMATE COMPOUND AND OPTICAL RESOLUTION METHOD THEREFOR

Provided is a manufacturing method for a piperidin-3-ylcarbamate compound in which a pyridin-3-ylcarbamate compound and hydrogen are brought into contact in the presence of a palladium catalyst.

PREVENTIVE OR THERAPEUTIC AGENTS FOR MULTIPLE SCLEROSIS

The preventive or therapeutic agents of the present invention for multiple sclerosis comprise compounds represented by the following formula (I), or salts or hydrates thereof, [wherein, T1, X, Z1, Z2, and R1 have the same meaning as T1, X, Z1, Z2, and R1 in this application].