184643-69-4

Basic information

• Product Name: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE
• Synonyms: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE;4-Bromo-1-methyl-2-(trichloroacetyl)-1H-pyrrole
• CAS NO: 184643-69-4
• Molecular Formula: C₇H₅BrCl₃NO
• Molecular Weight: 305.38
• Mol File: 184643-69-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 102-104°C
• Boiling Point: 335.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.79±0.1 g/cm3(Predicted)
• PKA: -12.51±0.70(Predicted)
• CAS DataBase Reference: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE(184643-69-4)
• EPA Substance Registry System: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE(184643-69-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 184643-69-4(Hazardous Substances Data)

Usage

General Description

The chemical 1-(4-Bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloro-1-ethanone, also known as bromchloron, is a synthetic organic compound with the molecular formula C7H6BrCl3NO. It is a yellow to brown solid with a strong, unpleasant odor. Bromchloron is primarily used as a pesticide and herbicide, and is effective against a wide range of insects and weeds. However, it is also highly toxic to aquatic organisms and can be persistent in the environment. It is important to handle and use bromchloron with caution, as exposure to this chemical can have harmful effects on human health and the environment.

Upstream product

• 96-54-8 N-Methylpyrrole 
• 21898-65-7 1-methyl-2-trichloroacetyl-1H-pyrrole 

Downstream Products

• 1146689-63-5 4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid [3-(2-benzenesulfinyl-3-dimethylsulfamoyl-3H-imidazol-4-yl)-propyl]-amide 
• 1428306-05-1 methyl 4-[[4-[[4-(4-aminophenyl)-1-methyl-pyrrole-2-carbonyl]amino]-1-methyl-imidazole-2-carbonyl]amino]-1-methyl-pyrrole-2-carboxylate 
• 1428306-03-9 C₂₉H₃₃N₇O₆ 

Relevant articles and documents

Design, Synthesis, and Fungicidal Evaluation of Novel Pyrazole-furan and Pyrazole-pyrrole Carboxamide as Succinate Dehydrogenase Inhibitors

The identification of novel succinate dehydrogenase (SDH) inhibitors represents one of the most attractive directions in the field of fungicide research and development. During our continuous efforts to pursue inhibitors belonging to this class, some structurally novel pyrazole-furan carboxamide and pyrazole-pyrrole carboxamide derivatives have been discovered via the introduction of scaffold hopping and bioisosterism to compound 1, a remarkably potent lead obtained by pharmacophore-based virtual screening. As a result of the evaluation against three destructive fungi, including Sclerotinia sclerotiorum, Rhizoctonia solani, and Pyricularia grisea, a majority of them displayed potent fungicidal activities. In particular, compounds 12I-i, 12III-f, and 12III-o exhibited excellent fungicidal activity against S. sclerotiorum and R. solani comparable to that of commercial SDHI thifluzamide and 1.

GC-Targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models

DNA binding 4-(1-methyl-1H-pyrrol-3-yl)benzenamine (MPB) building blocks have been developed that span two DNA base pairs with a strong preference for GC-rich DNA. They have been conjugated to a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) molecule to produce

PYRROLOBENZODIAZEPINES

Pyrrolobenzodiazepine (PBDs) having a (1-methyl-1H-pyrrol-3- yl)phenyl based amino residue were found to be highly effective compounds having improved cytotoxicity ad DNA binding properties.