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Sodium (2-Sulfonatoethyl)methanethiosulfonate, also known as MTSES, is a negatively-charged, membrane impermeant Methanethiosulfonate (MTS) compound. It is a white solid that is highly reactive with ionized thiolates but not with unionized thiols, targeting sulfhydryl groups accessible from the aqueous medium. MTSES is commonly used to study cysteine residues on proteins and probe the structural and functional properties of native proteins, particularly those associated with membranes, including channels and transporters.

184644-83-5

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184644-83-5 Usage

Uses

Used in Structural Biology:
Sodium (2-Sulfonatoethyl)methanethiosulfonate is used as a probe for [studying the structures of ACh receptor channel, GABAA receptor channel, and lactose permease] because it reacts specifically and rapidly with thiols to form mixed disulfides.
Used in Pharmaceutical Research:
Sodium (2-Sulfonatoethyl)methanethiosulfonate is used as a research tool for [investigating the structural and functional properties of native proteins, especially those associated with membranes] due to its high reactivity with ionized thiolates and its ability to target sulfhydryl groups accessible from the aqueous medium.
Used in Cysteine Scanning Mutagenesis:
Sodium (2-Sulfonatoethyl)methanethiosulfonate is used as a reagent for [studying non-cysteine residues] in combination with cysteine scanning mutagenesis, providing insights into the protein structure and function.
Used in Biochemistry and Molecular Biology:
Sodium (2-Sulfonatoethyl)methanethiosulfonate is used as a modifying agent for [cysteine residues on proteins] to study their role in protein folding, stability, and function.
Used in Drug Development:
Sodium (2-Sulfonatoethyl)methanethiosulfonate is used as a chemical tool for [developing drugs targeting proteins with cysteine residues], particularly those involved in membrane-associated processes.
Used in Analytical Chemistry:
Sodium (2-Sulfonatoethyl)methanethiosulfonate is used as an analytical reagent for [detecting and quantifying thiols] in various samples, including proteins and other biomolecules.

Check Digit Verification of cas no

The CAS Registry Mumber 184644-83-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,6,4 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 184644-83:
(8*1)+(7*8)+(6*4)+(5*6)+(4*4)+(3*4)+(2*8)+(1*3)=165
165 % 10 = 5
So 184644-83-5 is a valid CAS Registry Number.
InChI:InChI=1/C3H8O5S3.Na/c1-10(4,5)9-2-3-11(6,7)8;/h2-3H2,1H3,(H,6,7,8);/q;+1/p-1/rC3H7NaO5S3/c1-11(5,6)10-2-3-12(7,8)9-4/h2-3H2,1H3

184644-83-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name sodium,2-methylsulfonylsulfanylethanesulfonate

1.2 Other means of identification

Product number -
Other names Sodium 2-methylsulfonylsulfanylethanesulfonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:184644-83-5 SDS

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