184645-50-9

Upstream product

• 994-30-9 triethylsilyl chloride 
• 92950-42-0 13-dehydro-10-deacetylbaccatin III 

Downstream Products

• 285118-36-7 C₄₁H₆₄O₉Si₂ 
• 285118-35-6 C₄₁H₆₂O₉Si₂ 
• 358621-68-8 5⁽²⁰⁾-deoxy-5⁽²⁰⁾-sulfanyl-7,10-di(triethylsilyl)-13-[[(4S,5R)-2-(4-methoxyphenyl)-3-(tert-butyloxycarbonyl)-4-phenyl-1,3-oxazolidin-5-yl]carbonyl]-10-deacetylbaccatin III 
• 358621-67-7 7,10-di(triethylsilyl)-5⁽²⁰⁾-deoxy-5⁽²⁰⁾-sulfanyl-10-deacetylbaccatin III 
• 358621-66-6 7,10-di(triethylsilyl)-5⁽²⁰⁾-deoxy-5⁽²⁰⁾-sulfanyl-13-oxo-10-deacetylbaccatin III 

Relevant academic research and scientific papers

Synthesis of 5(20)deoxydocetaxel, a new active docetaxel analogue

5(20)Deoxydocetaxel was prepared from 13-oxo-10-deacetyl baccatin III. This compound is the first docetaxel analogue with a modified D-ring which is as active as paclitaxel off microtubules. (C) 2000 Elsevier Science Ltd.

Semisynthesis of D-ring modified taxoids: Novel thia derivatives of docetaxel

Two novel 5(20)-thia analogues of docetaxel have been synthesized from 10-deacetylbaccatin III or taxine B and isotaxine B. The key step of these syntheses is the concomitant thietane ring formation and acetylation of the tertiary alcohol at C-4. Both compounds are less cytotoxic than docetaxel but have divergent activity on microtubule disassembly.