18469-37-9

Basic information

• Product Name: 4-Bromo-N,N-dimethylbenzamide
• Synonyms: 4-Bromo-N,N-dimethylbenzamide;N,N-Dimethyl 4-bromobenzamide;benzamide, 4-bromo-N,N-dimethyl-;N,N-Dimethyl p-bromobenzamide;4-bromo-N,N-dimethylbenzamide(SALTDATA: FREE)
• CAS NO: 18469-37-9
• Molecular Formula: C₉H₁₀BrNO
• Molecular Weight: 228.1
• Product Categories: blocks;Bromides;Carboxes;alkyl bromide
• Mol File: 18469-37-9.mol
• Article Data: 50

Chemical Properties

• Melting Point: 76-79 °C
• Boiling Point: 320.9°Cat760mmHg
• Flash Point: 147.9°C
• Appearance: /
• Density: 1.417g/cm³
• Vapor Pressure: 0.000308mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.42±0.70(Predicted)
• CAS DataBase Reference: 4-Bromo-N,N-dimethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-N,N-dimethylbenzamide(18469-37-9)
• EPA Substance Registry System: 4-Bromo-N,N-dimethylbenzamide(18469-37-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 18469-37-9(Hazardous Substances Data)

Usage

General Description

4-Bromo-N,N-dimethylbenzamide is a chemical compound with the molecular formula C9H10BrNO. Its systematic name is 4-Bromo-N,N-dimethylbenzenecarboxamide. It is a benzamide, which is a class of compounds that consist of a benzene ring attached to an amide group. 4-Bromo-N,N-dimethylbenzamide has a molar mass of 243.08 g/mol. This chemical is used in various fields including pharmaceuticals and chemical research due to its substructures; aromatic bromides and amides are useful intermediates in organic synthesis. To handle and store the chemical, it is necessary to ensure a cool and dry environment. Overall, it is important to follow standard safety precautions while handling this chemical.

InChI:InChI=1/C9H10BrNO/c1-11(2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3

Upstream product

• 124-40-3 dimethyl amine 
• 586-75-4 4-chlorobenzoyl chloride 
• 107-13-1 acrylonitrile 
• 292638-85-8 acrylic acid methyl ester 
• 506-59-2 N,N-dimethylammonium chloride 
• 698-67-9 p-bromobenzamide 
• 74-88-4 methyl iodide 
• 1122-91-4 4-bromo-benzaldehyde 
• 873-75-6 4-bromobenzenemethanol 
• 68-12-2 N,N-dimethyl-formamide 
• 106-38-7 para-bromotoluene 
• 586-76-5 4-Bromobenzoic acid 
• 3959-07-7 4-Bromobenzylamine 
• 16532-79-9 4-Bromophenylacetonitrile 

Downstream Products

• 623-00-7 4-bromobenzenecarbonitrile 
• 71888-25-0 N,N-diethyl-p-<(dimethylamino)methyl>benzamide 
• 1253286-64-4 N₁,N₁-dimethyl-N₄-(pyrrolidin-1-ylsulfonyl)terephthalamide 
• 1255650-63-5 N₁,N₁-dimethyl-N₄-(piperidine-1-carbonyl)terephthalamide 
• 1207176-28-0 4-((4-cyano-1-phenyl-1H-pyrazol-3-yl)amino)-N,N-dimethylbenzamide 
• 134-81-6 benzil 
• 58287-76-6 4-(N,N-Dimethylcarbamoyl)benzaldehyde 
• 1083428-66-3 C₁₅H₁₅ClN₂OS 
• 1360607-89-1 4-((3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl)thio)N,N-dimethylbenzamide 
• 252017-04-2 AZD7545 
• 24167-56-4 N,N-dimethyl-4-fluorobenzamide 
• 7295-44-5 4'-bromovalerophenone 
• 24167-50-8 4-cyano-N,N-dimethylbenzamide 
• 611-74-5 N,N-dimethylbenzamide 

Relevant articles and documents

One-pot synthesis of a highly disperse core-shell CuO-alginate nanocomposite and the investigation of its antibacterial and catalytic properties

In this study, sodium alginate was extracted from Sargassum algae, collected from coastal waters of Bushehr, Persian Gulf, Iran and used as a stabilizing and wrapping agent for CuO nanoparticles. The synthesized nanocomposite was characterized by some spectroscopic and microscopic techniques, such as IR, XRD, Uv-vis, BET, BJH, zeta potential, SEM, TEM, HR-TEM, and XPS. The antibacterial effects of the CuO-alginate nanocomposite against some bacteria, isolated from a burn wound, were evaluated. The results showed that this nanocomposite had better antibacterial effects than its components onPseudomonas aeruginosaATCC 27853,Staphylococcus aureusATCC 12600,Streptococcus pyogenesATCC 19615, andStaphylococcus epidermidisATCC 49461. Among these,Staphylococcus aureusATCC 12600 was the most sensitive one to this nanocomposite, with the lowest minimum inhibitory concentration (2.08 mg mL?1) observed. Moreover, the synthesized nanocomposite showed good catalytic activity in the oxidative coupling of carboxylic acids withN,N-dialkylformamides toward the synthesis of amides.

N2-carbamylaryl-2-aminopyrimidine derivative and medical application thereof

The invention provides an N2-carbamylaryl-2-aminopyrimidine derivative and a medical application thereof. The N2-carbamylaryl-2-aminopyrimidine derivative provided by the invention comprises an optical isomer of the N2-carbamylaryl-2-aminopyrimidine derivative and pharmaceutically acceptable salt thereof. Pharmacodynamic research shows that the traditional Chinese medicine composition has no toxicor side effect, the compound has an FLT3 inhibitory activity. The proliferation inhibition activity is realized on various leukemia cell strains; a medium inhibition effect is achieved on breast cancer cells; moreover, the polypeptide is effective for multiple mutations of AML, such as internal tandem repeat mutation of a near-membrane structural domain and D835 point mutation of an activated ring in a kinase structural domain, almost has no inhibition effect on c-KIT, can overcome drug resistance brought by clinical point mutation, can reduce toxic and side effects of bone marrow inhibition,and can be applied to preparation of antitumor drugs. The structures of the general formulas Ia and Ib of the N2-carbamylaryl-2-aminopyrimidine derivative are shown in the specification,

AMINOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS

The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: (I) where A, B, R1, X1, X2, and W are described herein.