184709-73-7

Basic information

• Product Name: Carbamic acid, [2-(4-chlorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo- 1-(phenylmethyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester
• CAS NO: 184709-73-7
• Molecular Formula: C30H24ClF3N4O5
• Molecular Weight: 612.993
• Mol File: 184709-73-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-(4-chlorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo- 1-(phenylmethyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-(4-chlorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo- 1-(phenylmethyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester(184709-73-7)
• EPA Substance Registry System: Carbamic acid, [2-(4-chlorophenyl)-1,6-dihydro-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo- 1-(phenylmethyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester(184709-73-7)

Safety Data

• Hazardous Substances Data: 184709-73-7(Hazardous Substances Data)

Upstream product

• 124044-49-1 3-amino-1,1,1-trifluoro-4-phenyl-2-butanol 
• 184711-49-7 [1-[(1-benzyl-3,3,3-trifluoro-2-hydroxy-propylcarbamoyl)-methyl]-2-(4-chloro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester 
• 148748-42-9 [5-benzyloxycarbonylamino-2-(4-chlorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]acetic acid 

Relevant articles and documents

Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones

Chymase possesses a wide variety of actions, including promotion of angiotensin II production and histamine release from mast cells. However, due to a lack of effective inhibitors featuring both high inhibitory activity and high metabolic stability, the p