184769-87-7

Basic information

• Product Name: 3,5-dibromo-4-aminophenethyl alcohol
• Synonyms: 3,5-dibromo-4-aminophenethyl alcohol
• CAS NO: 184769-87-7
• Molecular Weight: 294.974
• Mol File: 184769-87-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3,5-dibromo-4-aminophenethyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dibromo-4-aminophenethyl alcohol(184769-87-7)
• EPA Substance Registry System: 3,5-dibromo-4-aminophenethyl alcohol(184769-87-7)

Safety Data

• Hazardous Substances Data: 184769-87-7(Hazardous Substances Data)

Upstream product

• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 

Downstream Products

• 250160-46-4 2-[3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-ethanol 
• 75894-93-8 1,3-dibromo-5-(2-hydroxyethyl)benzene 
• 1024500-31-9 2-(3,5-dibromo-4-iodophenyl)ethanol 
• 188966-32-7 [3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetic acid 
• 250160-47-5 [3,5-dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetic acid 
• 250160-49-7 (S)-2-((R)-2-{2-[3,5-Dibromo-4-(pyrrolidin-1-ylazo)-phenyl]-acetylamino}-2-phenyl-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 250160-50-0 (11R,14S)-5-Bromo-9,12-dioxo-11-phenyl-4-(pyrrolidin-1-ylazo)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester 
• 188966-36-1 (11R,14S)-4-Amino-9,12-dioxo-11-phenyl-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester 
• 476195-64-9 C₆₆H₉₆O₅Si₃ 
• 476195-63-8 C₆₄H₉₆O₃Si₃ 
• 1027302-33-5 C₅₆H₇₈Br₂O₅Si 
• 476195-65-0 {2-[3,5-bis-(3-dodecyloxy-5-ethynyl-phenylethynyl)-phenyl]-ethoxy}-tert-butyl-dimethyl-silane 
• 476195-71-8 O-tert-butyldimethylsilyl-2-(3,5-bis(trimethylsilylethynyl)phenyl)ethyl alcohol 
• 476195-61-6 O-tert-butyldimethylsilyl-2-(3,5-bis(ethynyl)phenyl)ethyl alcohol 

Relevant articles and documents

INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE

Compounds of formula (I) are inhibitors of p38 MAP kinase activity, and are useful in the treatment of, inter alia, inflammatory and autoimmune disease formula (I): wherein R3, R4, R5 and R6 are each independently hydrogen or halogen; M and P are independently -N= or -CH=; Z is (a) a radical of formula R1R2CHNH-Y-L1-X1-(CH2)Z-, wherein R1R2CHNH- is an N-linked amino acid or amino acid ester group as defined in the description, and -Y-L1-X1-(CH2)Z- is a linker radical as defined in the description.

Total synthesis of vancomycin - Part 1: Design and development of methodology

o-Halosubstituted aromatic triazenes (e.g. I, Scheme 1) react with aryloxides (e.g. II, Scheme 1) in the presence of CuBr · Me2S, K2CO3 and pyridine in acetonitrile at reflux to afford biaryl ethers (e.g. V, Scheme 1). This general methodology (Tables 1 and 2) was applied to the construction of the C-O-D and D-O-E vancomycin model systems 37 (Scheme 2) and 50 (Scheme 3), demonstrating its potential in a projected total synthesis of vancomycin (1. Figure 1). For the construction of the vancomycin model AB biaryl ring system, a sequential strategy involving a Suzuki coupling of the C-O-D aryl iodide 74 (Scheme 7) and boronic acid 53 (Scheme 4), followed by macrolactamization was demonstrated, in which the preformed C-O-D ring framework served to preorganize the precursor for cyclization. The latter investigation led to Suzuki-coupling-based asymmetric synthesis of biaryl systems in which 2,2-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) was found to be the optimum ligand (Tables 3 and 4).

Conformational preferences about both exocyclic carbon-carbon bonds in some phenyl derivatives of ethane, propene, and 4-picoline

The 1H nmr spectra in solution of 1-R-(3,5-dibromophenyl)ethanes (R = CH3, C2H5, n-C3H7 to n-C6H13, OH, F, Br), of 1-amino-2-(3,5-dichlorophenyl)ethane, of 3,5-dichloroallylbenzene, and of 4-(3,5-dibromobenzyl)pyridine are analyzed at 305 K.For the ethane