Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1848-84-6

Post Buying Request

1848-84-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1848-84-6 Usage

Synthesis Reference(s)

Tetrahedron, 53, p. 457, 1997 DOI: 10.1016/S0040-4020(96)01009-5

Check Digit Verification of cas no

The CAS Registry Mumber 1848-84-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,4 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1848-84:
(6*1)+(5*8)+(4*4)+(3*8)+(2*8)+(1*4)=106
106 % 10 = 6
So 1848-84-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N2/c1-2-9-10-7-5-3-4-6-8(7)11-9/h3-6H,2H2,1H3,(H,10,11)

1848-84-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-ethyl-1H-benzimidazole

1.2 Other means of identification

Product number -
Other names EINECS 217-433-8

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1848-84-6 SDS

1848-84-6Relevant articles and documents

Zwitterions as intermediates in 1,3-dipolar cycloadditions of electrophilic azides to 2-alkylidenetetrahydroimidazoles and 2-alkylidenedihydrobenzimidazoles

Quast, Helmut,Ach, Manfred,Ivanova, Svetlana,Peters, Eva-Maria,Peters, Karl,Von Schnering, Hans Georg

, p. 1551 - 1558 (1996)

Cyclic ketene N,N-acetals derived from imidazolidine (4a, c) and 2,3-dihydrobenzimidazole (6a-c) add methanesulphonyl azide (2 a) or picryl azide (2f) to afford the zwitterions 5 and 7, respectively. The structure of 7d is elucidated by X-ray crystallography. Reversibility of formation and thermal stability of the N-sulphonyl zwitterions depend on the substitution pattern at the carbon atom to which the triazenide moiety is attached: In the case of a pair of geminal methyl groups (5a, 7a) formation is irreversible and decomposition by cyclisation and subsequent reactions occurs above -20°C, while in presence of a single alkyl group (7c, d) these processes require heating to 80°C and are accompanied by partial reversion to 2a and ketene N,N-acetals (6b, c). Cyclisation of the zwitterions yields intermediate spirocyclic [3 + 2] cycloadducts, which may undergo [3 + 2] cycloreversion into N-sulphonylimine 13 and diazo compound 14 or extrude molecular nitrogen to furnish ring-expanded 2-(sulphonyl-imino)piperazine derivatives (9, 11). VCH Verlagsgesellschaft mbH, 1996.

Visible light initiated oxidative coupling of alcohols ando-phenylenediamines to synthesize benzimidazoles over MIL-101(Fe) promoted by plasmonic Au

Hao, Mingming,Li, Zhaohui,Qin, Yuhuan,Xu, Chao

, p. 4161 - 4169 (2021)

The use of visible light to initiate one-pot synergistic/cascade reactions is a green and energy saving strategy. In this manuscript, we report that MIL-101(Fe) can act as a multifunctional catalyst to realize the oxidative condensation betweeno-phenylenediamines and alcohols to synthesize benzimidazoles under visible light. The deposition of plasmonic Au nanoparticles (Au NPs) on MIL-101(Fe) led to significantly improved activity. Both controlled experiments and electron spin resonance (ESR) results revealed that the production of benzimidazoles fromo-phenylenediamines and alcohols involves three sequential steps,i.e., the oxidative dehydrogenation of alcohols to produce aldehydes, the condensation betweeno-phenylenediamines and the aldehydes to produce Schiff bases and their oxidation to form benzimidazoles,viaa superoxide radical (O2˙?)-mediated pathway. The promoting effect of plasmonic Au NPs in this reaction can be ascribed to the effective transfer of the surface plasmon resonance (SPR)-excited hot electrons to the lowest unoccupied molecular orbital (LUMO) of MIL-101(Fe), which led to the generation of more active O2˙?radicals. This study not only provides a green and sustainable way for the synthesis of benzimidazoles, but also highlights the great potential of using rationally designed plasmonic metal NP/MOF nanocomposites as multifunctional catalysts for light initiated one-pot tandem/cascade reactions.

The Transition Metal-catalyzed N-Heterocyclization. A Reductive Trasformation of Aminonitroarenes and Dinitroarenes into Phenanthroline Derivatives Using Aliphatic Aldehydes under Carbon Monoxide Pressure

Watanabe, Yoshihisa,Suzuki, Naoki,Tsuji, Yasushi

, p. 2445 - 2449 (1982)

The Catalytic N-heterocyclization of aminoarenes and dinitroarenes using aliphatic n-C3-C5 aldehydes was carried out at 180 deg C under the pressure of carbon monoxide (70 atm at room temperature) in the presence of RhCl(PPh3)3 and PdCl2 as a binary catalyst system.The reaction of p-nitroaniline with propanal, butanal, and pentanal gave 3,8-diethyl-2,9-dimethyl-4,7-phenanthroline, 2,9-diethyl-3,8-dipropyl-4,7-phenanthroline, and 3,8-dibutyl-2,9-dipropyl-4,7-phenantroline in 43, 57, and 54percent yields respectively.On the other hand, m-nitroaniline and o-nitroaniline gave 1,7-phenanthroline and imidazole derivatives in rather low yields (21 and 24percent) under the reaction conditions employed.

A green chemical synthesis of 2-alkylbenzimidazoles from 1,2-phenylenediamine and propylene glycol, or alcohols mediated by Ag-TiO 2/clay composite photocatalyst

Selvam,Swaminathan

, p. 1060 - 1061 (2007)

Benzimidazole derivatives were synthesized in good yield from 1,2-phenylenediamine (PD) and various alcohols by photocatalytic cyclization with TiO2 /acidic clay composite catalyst using UV-A and solar light. Doping silver on TiO2 enhances product yield and selectivity of the photocatalytic synthesis of benzimidazoles. The higher efficiency of nano-Ag-doped TiO2 in solar light makes this synthesis a green chemical process. Copyright

Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB

Chandrasekera, N. Susantha,Berube, Bryan J.,Shetye, Gauri,Chettiar, Somsundaram,O'Malley, Theresa,Manning, Alyssa,Flint, Lindsay,Awasthi, DIvya,Ioerger, Thomas R.,Sacchettini, James,Masquelin, Thierry,Hipskind, Philip A.,Odingo, Joshua,Parish, Tanya

, p. 898 - 916 (2017)

The phenoxy alkyl benzimidazoles (PABs) have good antitubercular activity. We expanded our structure-activity relationship studies to determine the core components of PABs required for activity. The most potent compounds had minimum inhibitory concentrations against Mycobacterium tuberculosis in the low nanomolar range with very little cytotoxicity against eukaryotic cells as well as activity against intracellular bacteria. We isolated resistant mutants against PAB compounds, which had mutations in either Rv1339, of unknown function, or qcrB, a component of the cytochrome bc1 oxidase of the electron transport chain. QcrB mutant strains were resistant to all PAB compounds, whereas Rv1339 mutant strains were only resistant to a subset, suggesting that QcrB is the target. The discovery of the target for PAB compounds will allow for the improved design of novel compounds to target intracellular M. tuberculosis.

Density functional treatment and electro analytical measurements of liquid phase interaction of 2-ethylbenzimidazole (EBI) and ethyl (2-ethylbenzimidazolyl) acetate (EEBA) on mild steel in hydrochloric acid

Mohan, Revathi,Ramya,Anupama,Joseph, Abraham

, p. 707 - 717 (2016)

DFT calculations on the liquid phase interaction and corrosion inhibition properties of 2-ethylbenzimidazole (EBI) and its derivative ethyl (2-ethylbenzimidazolyl)acetate (EEBA) on mild steel in hydrochloric acid (0.5, 5 and 1.5 M) at three different temperatures (303, 308 and 313 K) have been studied using EIS, polarization, adsorption measurements and computational calculations. Results show that EBI and EEBA act as effective inhibitors for the corrosion of mild steel in hydrochloric acid media. Polarization studies showed that both the inhibitors behave as mixed type inhibitors with respect to the electrode reactions. EEBA offers better inhibition efficiency than EBI. The inhibition efficiency found to decrease with increase in temperature in either of the cases. The mechanism involves adsorption phenomenon and in the case of EEBA, the adsorption obeyed Langmuir adsorption isotherm. For EBI, the adsorption obeyed Langmuir adsorption isotherm except for 313 K in 1.5 M HCl, for which the best fit adsorption isotherm was Temkin adsorption isotherm.

Ammonium sulphate-magnesium selective reduction of N-2-nitrophenylimidates: Synthesis of 2-substituted benzimidazoles

Harizi, Abdallah,Zantour, Hedi

, p. 387 - 392 (2002)

Various N-2-nitrophenylimidates were selectively reduced by (NH4)2SO4-Mg to the non-isolated N-2-aminophenylimidates which cyclise to the corresponding 2-substituted benzimidazoles.

Simple inorganic base promoted C-N and C-C formation: synthesis of benzo[4,5]imidazo[1,2-a]pyridines as functional AIEgens used for detecting picric acid

Yang, Kai,Luo, Shi-He,Chen, Si-Hong,Cao, Xi-Ying,Zhou, Yong-Jun,Lin, Yan-Lan,Huo, Yan-Ping,Wang, Zhao-Yang

supporting information, p. 8133 - 8139 (2021/10/04)

Metal-free catalyzed intermolecular tandem Michael addition/cyclization has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]pyridines from α-bromocinnamaldehyde and 2-substituted benzimidazoles. The reaction promoted by a simple inorganic base displays moderate to good yields and good functional group tolerance. The optical properties of some typical products have been investigated. We found that, due to the presence of the benzene ring at the C1-position of benzo[4,5]imidazo[1,2-a]pyridines which restricts intramolecular motion, as a new type of aggregation-induced emission (AIE) luminogen (AIEgen), they show very good solid-state fluorescence with quantum yields up to 88.80%. Importantly, the AIE performance of compound3bcan be useful to detect the nitroaromatic explosive picric acid (PA) with a detection limit and quenching constant of 42.5 nM and 7.27 × 104M?M, respectively.

Fluorinated phosphoric acid as a versatile effective catalyst for synthesis of series of benzimidazoles, benzoxazoles and benzothiazoles at room temperature

Mathapati, Sushil R.,Patil, Komal N.,Mathakari, Sujit S.,Suryawanshi, Appasaheb W.,Jadhav, Arvind H.

, p. 538 - 547 (2021/01/21)

The present work describes synthesis of a series of benzimidazoles, benzoxazoles and benzothiazoles through the cyclization of 1, 2-phenylenediamine, 2-aminothiophenol, or 2-aminophenol with aryl, aliphatic and heteroaryl aldehydes. The present synthetic protocol is very much efficient in presence of 5 mol % fluorophosphoric acid as a catalyst in ethanol solvent at room temperature. Shorter reaction time, simple work-up technique, high yields and easy availability are specific compensations of the present synthetic approach.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1848-84-6