1848223-48-2Relevant academic research and scientific papers
Adjusting the Structure of 2′-Modified Nucleosides and Oligonucleotides via C4′-α-F or C4′-α-OMe Substitution: Synthesis and Conformational Analysis
Malek-Adamian, Elise,Patrascu, Mihai Burai,Jana, Sunit Kumar,Martínez-Montero, Saúl,Moitessier, Nicolas,Damha, Masad J.
, p. 9839 - 9849 (2018)
We report the first syntheses of three nucleoside analogues, namely, 2′,4′-diOMe-rU, 2′-OMe,4′-F-rU, and 2′-F,4′-OMe-araU, via stereoselective introduction of fluorine or methoxy functionalities at the C4′-α-position of a 4′,5′-olefinic intermediate. Conf
