184844-14-2

Upstream product

• 600-22-6 pyruvic acid methyl ester 
• 136159-65-4 (S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one 

Downstream Products

• 207686-03-1 (2S,3R)-3-Benzyl-2-hydroxy-N-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethyl]-2-methyl-succinamic acid methyl ester 
• 207686-10-0 (2S,3R)-3-Benzyl-2-hydroxy-N-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethyl]-2-methyl-succinamic acid 

Relevant academic research and scientific papers

Asymmetric reactions of chiral imide enolates with α-keto esters

A method for the synthesis of a variety of 2-hydroxy-2,3-trisubstituted succinates (I) is presented. The synthesis is achieved by the asymmetric reactions of lithium, boron or titanium enolates of Evans' chiral imides with α-keto esters.

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Examination of the S1 area of the active site of pro-stromelysin has led us to the design of novel and potent inhibitors of matrix metalloproteinases containing constrained quaternary-hydroxy group at P1. The synthesis and biological activity of these compounds with variations at P1', P2', and P3' will be described.