184873-67-4

Basic information

• Product Name: (R)-5-((S)-2-Benzyloxy-1-hydroxy-ethyl)-dihydro-furan-2-one
• Synonyms: (R)-5-((S)-2-Benzyloxy-1-hydroxy-ethyl)-dihydro-furan-2-one
• CAS NO: 184873-67-4
• Molecular Weight: 236.268
• Mol File: 184873-67-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-5-((S)-2-Benzyloxy-1-hydroxy-ethyl)-dihydro-furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-((S)-2-Benzyloxy-1-hydroxy-ethyl)-dihydro-furan-2-one(184873-67-4)
• EPA Substance Registry System: (R)-5-((S)-2-Benzyloxy-1-hydroxy-ethyl)-dihydro-furan-2-one(184873-67-4)

Safety Data

• Hazardous Substances Data: 184873-67-4(Hazardous Substances Data)

Upstream product

• 93553-66-3 1-(benzyloxy)but-3-en-2-ol 
• 667870-34-0 (4E)-ethyl-6-benzyloxy hex-4-enoate 
• 23791-01-7 Acetic acid (2S,3R)-2-acetoxymethyl-6-oxo-tetrahydro-pyran-3-yl ester 
• 312264-25-8 (5R)-2-(Z)-tert-butoxycarbonylmethylidene-5-[(1S)-1-acetyloxy-2-benzyloxyethyl]tetrahydrofuran 
• 312264-26-9 (5R,6S)-5-acetyloxy-6-benzyloxymethyl-2-(E)-tert-butoxycarbonylmethylidenetetrahydropyran 
• 312264-27-0 (5R)-5-[(1S)-1-acetyloxy-2-benzyloxyethyl]butyrolactone 

Downstream Products

• 62-46-4 (S)-lipoic acid 
• 70606-00-7 (R)-tetrahydro-5-oxo-2-furancarbaldehyde 
• 184873-68-5 Tetradecanoic acid (S)-2-benzyloxy-1-((R)-5-oxo-tetrahydro-furan-2-yl)-ethyl ester 

Relevant articles and documents

Chirality induction and chiron approaches to enantioselective total synthesis of α-lipoic acid

Abstract An efficient, short and convenient asymmetric synthesis of (R)-(+)-lipoic acid in seven steps from chiral hydroxy aldehyde with 32.5% overall yield is described. Synthesis of S and R enantiomers of α-lipoic acid from cis-1,4-butene diol derived chiral lactone is reported with 34 % overall yield. The present synthesis involves use of simple reaction conditions making it a convenient synthesis.

Conformationally constrained analogues of diacylglycerol. 13. Protein kinase C ligands based on templates derived from 2,3-dideoxy-L- erythro(threo)-hexono-1,4-lactone and 2-deoxyapiolactone

In the present investigation, the last two possible modes of generating conformationally semirigid diacylglycerol (DAG) analogues embedded into five- membered ring lactones as templates III and IV are investigated. The first two templates studied in previ