184879-34-3

Basic information

• Product Name: 3-(4-Chloro-phenyl)-2-(4-isopropyl-phenoxy)-butyric acid ethyl ester
• Synonyms: 3-(4-Chloro-phenyl)-2-(4-isopropyl-phenoxy)-butyric acid ethyl ester
• CAS NO: 184879-34-3
• Molecular Weight: 360.881
• Mol File: 184879-34-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-Chloro-phenyl)-2-(4-isopropyl-phenoxy)-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Chloro-phenyl)-2-(4-isopropyl-phenoxy)-butyric acid ethyl ester(184879-34-3)
• EPA Substance Registry System: 3-(4-Chloro-phenyl)-2-(4-isopropyl-phenoxy)-butyric acid ethyl ester(184879-34-3)

Safety Data

• Hazardous Substances Data: 184879-34-3(Hazardous Substances Data)

Upstream product

• 14804-61-6 1-(1-bromoethyl)-4-chlorobenzene 
• 184878-99-7 ethyl (4-isopropylphenoxy)acetate 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 99-89-8 4-Isopropylphenol 

Relevant articles and documents

Glucose transport-enhancing and hypoglycemic activity of 2-methyl-2- phenoxy-3-phenylpropanoic acids

A series of 2-phenoxy-3-phenylpropanoic acids has been prepared which contains many potent hypoglycemic agents as demonstrated by assessing glucose lowering in ob/ob mice. Some compounds (32, 33, 59) normalize plasma glucose in this diabetic model at doses of approximately 1 mg/kg. The mechanism of action of these drugs may involve enhanced glucose transport, especially in fat cells, but the compounds do not stimulate GLUT4 translocation and do not increase the levels of GLUT1 or GLUT4 in vivo. Thus, these compounds may enhance the intrinsic activity of the glucose transporter GLUT1 or GLUT4. Some compounds also modestly decrease hepatocyte gluconeogenesis in vitro, but this is not likely to be a major contributor to the hypoglycemic effect observed in vivo. Likewise, a modest decrease in food consumption observed with some of these compounds was shown by a pair-feeding experiment not to be the primary cause of the hypoglycemia observed.