184879-74-1Relevant academic research and scientific papers
Synthesis of 1,2,5,6-tetrahydro-3-pyridinylalanine: A key intermediate in the preparation of thrombin inhibitor UK-239,326
Fish, Paul V.,Brown, Alan D.,Danilewicz, John C.,Ellis, David,Hardstone, J. David,James, Keith
experimental part, p. 2787 - 2798 (2009/04/11)
A short synthesis of N-protected 1,2,5,6-tetrahydro-3-pyridinylalanine derivatives (8-10) was accomplished using a simple procedure of quaternization of (3-pyridyl)alanine 6 with benzyl bromide followed by reduction with NaBH4. Amino acid 10 was then converted to thrombin inhibitor UK-239,326 (2), which required the sequential functionalization of four amines to give four different functional groups (viz., sulfonamide, carboxamide, guanidine, and methylamine). Copyright Taylor & Francis Group, LLC.
