184896-34-2

Upstream product

• 5428-54-6 2-methyl-5-nitrophenol 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 61570-79-4 1,1-dimethyl-2-propynyl trifluoroacetate 
• 99-55-8 2-methyl-5-nitroaniline 

Downstream Products

• 1099831-90-9 2,2,8-trimethyl-5-(phenylamino)chroman-4-one 
• 23095-44-5 girinimbine 
• 27300-29-4 3',3'-dimethylpyrano[3,2-a]carbazole-3-carbaldehyde 

Relevant academic research and scientific papers

Palladium-catalyzed total synthesis of euchrestifoline using a one-pot Wacker oxidation and double aromatic C-H bond activation

We describe the total synthesis of euchrestifoline featuring an unprecedented one-pot Wacker oxidation and double aromatic C-H bond activation. The 2008 Royal Society of Chemistry.

Enantioselective Total Synthesis and Assignment of the Absolute Configuration of the Furo[3,2- a]carbazole Alkaloid Furoclausine-B

We describe the first enantioselective total synthesis and the assignment of the absolute configuration of the furo[3,2-a]carbazole alkaloid furoclausine-B. As key steps for our approach we used a palladium(II)-catalyzed double C-H-bond activation for the

Transition metal complexes in organic synthesis. Part 33. Molybdenum-mediated total synthesis of girinimbine, murrayacine, and dihydroxygirinimbine

A highly convergent total synthesis of the pyrano[3,2-a]carbazole alkaloids girinimbine, murrayacine, and dihydroxygirinimbine has been accomplished using a consecutive molybdenum-mediated C-C- and C-N-bond formation.

Preparation method of pyran[3,2-a]carbazole compound

The invention relates to a preparation method of a pyran[3,2-a]carbazole compound represented by the formula (I). The preparation method comprises following steps: step one, taking 5-nitro-phenol as raw material to synthesize 3-(3'-3'-dimethylbutyne ether)-nitrobenzene; step two, preparing pyran[3,2-a]nitrobenzene from 3-(3'-3'-dimethylbutyne ether)-nitrobenzene through 3,3-sigma migration reactions between terminal alkyne hydrogen and a benzene ring system; step three, reducing pyran[3,2-a]nitrobenzene to obtain pyran[3,2-a]aniline; step four, preparing pyran[3,2-a]diphenylamine from pyran[3,2-a]aniline and aryl halide; and step five, preparing the pyran[3,2-a]carbazole compound from pyran[3,2-a]diphenylamine. The provided preparation method has the advantages that the steps of the synthesis route are few, the reaction conditions are mild, the adverse reactions are effectively reduced, the substrate universality is good, and the yield of target compound is high.

Synthesis of Euchrestifoline Using Iron- and Palladium-Catalyzed C–H Bond Activations

We describe a short and efficient synthetic route to euchrestifoline. Key steps of our approach are the iron(III)-catalyzed Wacker-type oxidation of a chromene derivative with hexadecafluorophthalocyanine-iron (FePcF16) as catalyst, a palladium(0)-catalyzed Buchwald–Hartwig amination, and the final palladium(II)-catalyzed oxidative cyclization of the resulting diarylamine to the natural product.