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Thiourea, N-2-benzothiazolyl-N'-(4-methylphenyl)-, also known as 2-(4-methylphenyl)-2-(1,3-benzothiazol-2-yl)-1,3-thiazol-4-amine, is a chemical compound with the molecular formula C15H12N4S2. It is a white to off-white crystalline solid with a molecular weight of 324.41 g/mol. Thiourea, N-2-benzothiazolyl-N'-(4-methylphenyl)- is characterized by the presence of a thiourea group, a benzothiazole ring, and a 4-methylphenyl group. It is primarily used as a chemical intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Due to its complex structure, it is often synthesized through multi-step processes involving various chemical reactions. The compound is typically stored in a cool, dry place and handled with care due to its potential reactivity with other substances.

1849-83-8

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1849-83-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1849-83-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,4 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1849-83:
(6*1)+(5*8)+(4*4)+(3*9)+(2*8)+(1*3)=108
108 % 10 = 8
So 1849-83-8 is a valid CAS Registry Number.

1849-83-8Relevant academic research and scientific papers

New thiourea and 1,3-thiazolidin-4-one derivatives effective on the HIV-1 virus

Bielenica, Anna,Sanna, Giuseppina,Madeddu, Silvia,Struga, Marta,Jó?wiak, Micha?,Kozio?, Anna E.,Sawczenko, Aleksandra,Materek, Ilona B.,Serra, Alessandra,Giliberti, Gabriele

, p. 883 - 891 (2017/10/05)

Thiourea derivatives have been reported to possess many biological activities, among them antiviral and antitumoral properties. As part of our continuing effort to develop new active compounds, we report the synthesis and the evaluation of new fifteen thiourea derivatives with 1,3-benzothiazole-2-yl moiety, among them a group of biologically active (1–7) also underwent cyclization to 1,3-thiazolidin-4-ones. Molecular structure of four compounds (4, 13, 15 and 3a) was determined by an X-ray crystallography. We here report the evaluation of their cytotoxicity against human leukaemia/lymphoma- and solid tumour-derived cell lines and of their antiviral activity against HIV-1 and representatives of ssRNA and dsDNA viruses. Derivative 5 showed an interesting activity against HIV-1 wild type and against variants carrying clinically relevant mutations. A colorimetric enzyme immunoassay clarified its mode of action as a non-nucleoside inhibitor of the reverse transcriptase.

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