184906-25-0

Basic information

• Product Name: 3-(2-Hydroxy-2-methylpropyl)-2,6-dimethylphenol
• Synonyms: 3-(2-Hydroxy-2-methylpropyl)-2,6-dimethylphenol
• CAS NO: 184906-25-0
• Molecular Weight: 194.274
• Mol File: 184906-25-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(2-Hydroxy-2-methylpropyl)-2,6-dimethylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Hydroxy-2-methylpropyl)-2,6-dimethylphenol(184906-25-0)
• EPA Substance Registry System: 3-(2-Hydroxy-2-methylpropyl)-2,6-dimethylphenol(184906-25-0)

Safety Data

• Hazardous Substances Data: 184906-25-0(Hazardous Substances Data)

Upstream product

• 184906-24-9 3-(2-Hydroxy-2-methylpropyl)-2,6-bis[(4-methoxybenzylsulfanyl)methyl]phenol 
• 184906-23-8 4-Bromo-3-(2-hydroxy-2-methyl-propyl)-2,6-bis-pyrrolidin-1-ylmethyl-phenol 
• 184906-22-7 4-Bromo-3-(2-hydroxy-2-methylpropyl)phenol 
• 189019-37-2 3-(2-hydroxy-2-methyl-propyl)-phenol 
• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 

Relevant articles and documents

Cyclic nitrones

The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.

Design, synthesis, and in vitro evaluation of cyclic nitrones as free radical traps for the treatment of stroke

Analogs of the cyclic nitrone free radical trap 1 (3,3-dimethyl-3,4- dihydroisoquinoline N-oxide, a cyclic analog of phenyl-tert-butylnitrone (PBN)) were prepared in which (1) the fused phenyl ring was replaced with a naphthalene ring, an electron rich heterocycle, or a dimethylphenol, (2) the nitrone-containing ring comprised five, six, or seven atoms, and (3) the gem- dimethyl group was replaced with spirocyclic groups. The most active antioxidant, which bears a dimethylphenol fused to a 7-membered ring nitrone (compound 6h), inhibited lipid peroxidation in vitro with an IC50 of 22 μM, a 75-fold improvement over that of 1. The previously observed correlation between lipophilicity and activity vs lipid peroxidation in vitro has been further substantiated and refined by this study. Moreover, certain classes of compounds (namely, dimethylphenols 6g, h and furan 6j) have now been found which are considerably more active in vitro than expected on the basis of their log k'(w) values.