184968-83-0

Usage

InChI:InChI=1/C16H28N2O3/c1-16(2,3)21-15(20)17-10-7-13(8-11-17)12-18-9-5-4-6-14(18)19/h13H,4-12H2,1-3H3

Upstream product

• 675-20-7 piperidin-2-one 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 6457-49-4 4-piperidinemethanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 184968-81-8 C₁₆H₂₉ClN₂O₃ 

Downstream Products

• 184968-86-3 4-(2-thioxo-piperidin-1-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 184968-88-5 1,1-dimethylethyl 4-(1-piperidinylmethyl)-1-piperidinecarboxylate 

Relevant academic research and scientific papers

SUBSTITUTED OXIMES AS NEUROKININ ANTAGONISTS

Compounds within the genus represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R is H, methyl, ethyl, -CH2CN, -CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -CH2C(O)NHCH2SO3H, (a), (b), (c), (d) or (e); R is methyl or ethyl; and Z is substituted piperidinyl.

Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors

The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-4(Z)- (methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors.