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L-Leucine, N-[(acetylthio)acetyl]-N-hydroxy-, also known as N-Acetyl-L-leucyl-L-leucyl-L-norleucinal or Ac-Leu-Leu-NH-Norleu, is a synthetic chemical compound that serves as a potent inhibitor of the proteasome, a complex of enzymes essential for the degradation of intracellular proteins. Its ability to block protein breakdown results in the accumulation of damaged or misfolded proteins within cells, which can be leveraged for therapeutic purposes in treating diseases such as cancer and neurodegenerative disorders.

185015-34-3

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185015-34-3 Usage

Uses

Used in Pharmaceutical Research and Development:
L-Leucine, N-[(acetylthio)acetyl]-N-hydroxyis used as a research tool for studying the role of the proteasome in various biological processes and diseases. Its inhibitory effect on the proteasome aids in understanding the mechanisms of protein degradation and its implications in cellular function and dysfunction.
Used in Cancer Therapy:
L-Leucine, N-[(acetylthio)acetyl]-N-hydroxyis used as a therapeutic agent for the treatment of cancer. By inhibiting the proteasome, it can lead to the accumulation of misfolded proteins, which can disrupt cellular processes and induce cell death in cancer cells, making it a potential candidate for cancer treatment.
Used in Neurodegenerative Disorder Research:
L-Leucine, N-[(acetylthio)acetyl]-N-hydroxyis used as a research compound to investigate the role of the proteasome in neurodegenerative disorders, where the accumulation of misfolded proteins is a common pathological feature. Its ability to modulate protein degradation can provide insights into the development of therapeutic strategies for such disorders.
Used in Drug Development:
L-Leucine, N-[(acetylthio)acetyl]-N-hydroxyis used as a lead compound in the development of drugs targeting specific enzymes involved in protein degradation. Its inhibitory properties can be optimized to create more selective and potent drugs for the treatment of various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 185015-34-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,0,1 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 185015-34:
(8*1)+(7*8)+(6*5)+(5*0)+(4*1)+(3*5)+(2*3)+(1*4)=123
123 % 10 = 3
So 185015-34-3 is a valid CAS Registry Number.

185015-34-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-[(2-acetylsulfanylacetyl)-hydroxyamino]-4-methylpentanoic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:185015-34-3 SDS

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