185121-91-9Relevant academic research and scientific papers
Asymmetric syntheses of chiral allylic alcohols
Schneider, Christiane,Kazmaier, Uli
, p. 1314 - 1320 (1998)
Chiral allylic alcohols 2 can easily be obtained by elimination from iodo ketals 10. These are available from natural sources, or by application of the asymmetric Sharpless dihydroxylation to vinylogous esters 6, subsequent reduction, halogenation and elimination. This protocol allows the synthesis of highly functionalized allylic alcohols, which can be used in asymmetric Claisen rearrangements.
