185122-75-2 Usage
Description
5H-Cyclopenta[b]pyridin-7-amine, 6,7-dihydrois a heterocyclic amine belonging to the cyclopenta[b]pyridine derivatives class. It features a cyclopentane ring fused to a pyridine ring, with a primary amine group attached at the seventh carbon atom. 5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDROmay have potential pharmaceutical applications due to its diverse biological activities, such as antifungal, antiviral, and anticancer properties. Its dihydro form indicates a reduced state, which may influence its reactivity and biological activity. This chemical compound holds promise as a valuable tool in drug discovery, development, and medicinal chemistry research.
Uses
Used in Pharmaceutical Applications:
5H-Cyclopenta[b]pyridin-7-amine, 6,7-dihydrois used as a potential pharmaceutical agent for its diverse biological activities, including antifungal, antiviral, and anticancer properties. Its heterocyclic amine structure contributes to its therapeutic potential in various medical applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5H-Cyclopenta[b]pyridin-7-amine, 6,7-dihydroserves as a building block for the synthesis of more complex chemical compounds. Its unique structure and reduced state may offer new avenues for the development of novel therapeutic agents and contribute to the advancement of drug discovery.
Used in Drug Synthesis:
5H-Cyclopenta[b]pyridin-7-amine, 6,7-dihydrois used as a key intermediate in the synthesis of various pharmaceutical compounds. Its heterocyclic nature and functional groups provide opportunities for further chemical modifications, enabling the creation of new drugs with improved efficacy and selectivity.
Used in Drug Discovery:
As a chemical compound with potential pharmaceutical applications, 5H-Cyclopenta[b]pyridin-7-amine, 6,7-dihydrois utilized in drug discovery processes. Its diverse biological activities and unique structural features make it a promising candidate for the development of new therapeutic agents targeting various diseases and conditions.
Used in Chemical Research:
5H-Cyclopenta[b]pyridin-7-amine, 6,7-dihydrois employed in chemical research to explore its reactivity, stability, and potential interactions with other molecules. Understanding its properties and behavior can contribute to the advancement of chemical knowledge and the development of new synthetic methods and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 185122-75-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,1,2 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 185122-75:
(8*1)+(7*8)+(6*5)+(5*1)+(4*2)+(3*2)+(2*7)+(1*5)=132
132 % 10 = 2
So 185122-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2/c9-7-4-3-6-2-1-5-10-8(6)7/h1-2,5,7H,3-4,9H2
185122-75-2Relevant articles and documents
Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication
Skerlj, Renato T.,Bridger, Gary J.,Kaller, Al,McEachern, Ernest J.,Crawford, Jason B.,Zhou, Yuanxi,Atsma, Bem,Langille, Jonathon,Nan, Susan,Veale, Duane,Wilson, Trevor,Harwig, Curtis,Hatse, Sigrid,Princen, Katrien,De Clercq, Erik,Schols, Dominique
body text, p. 3376 - 3388 (2010/09/05)
The redesign of azamacrocyclic CXCR4 chemokine receptor antagonists resulted in the discovery of novel, small molecule, orally bioavailable compounds that retained T-tropic (CXCR4 using, X4) anti-HIV-1 activity. A structure-activity relationship (SAR) was determined on the basis of the inhibition of replication of X4 HIV-1 NL4.3 in MT-4 cells. As a result of lead optimization, we identified (S)-N′-((1H-benzo[d]imidazol-2-yl)methyl)- N′-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine (AMD070) 2 as a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay. Compound 2 inhibited the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 2 and 26 nM, respectively, while remaining noncytotoxic to cells at concentrations exceeding 23 μM. The pharmacokinetics of 2 was evaluated in rat and dog, and good oral bioavailability was observed in both species. This compound represents the first small molecule orally bioavailable CXCR4 antagonist that was developed for the treatment of HIV-1 infection.
SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS
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Page/Page column 32, (2008/12/04)
Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.
Substituted aryl 1,4-pyrazine derivatives
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, (2008/06/13)
Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.