185138-92-5Relevant articles and documents
Enantioselective total synthesis of taurospongin A
Lebel, Helene,Jacobsen, Eric N.
, p. 9624 - 9625 (1998)
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Synthesis of taurospongin A
Wu, Boshen,Mallinger, Aurelie,Robertson, Jeremy
supporting information; experimental part, p. 2818 - 2821 (2010/09/03)
(Figure presented) Two new routes to the C(1-10) carboxylic acid core of taurospongin A are presented. In the first route, overall asymmetric hydration of a C(2)-C(3) alkene is achieved by Sharpless AD and selective deoxygenation at C(2); in the second route, the C(3) stereogenic center is set by Tietze asymmetric allylation. A short synthesis of the C(1′-25′) fatty acid combines with the product from the first route to complete the total synthesis of taurospongin A.
Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using pi-allyltricarbonyliron lactone complexes.
Hollowood, Christopher J,Ley, Steven V,Yamanoi, Shigeo
, p. 1624 - 1625 (2007/10/03)
The synthesis of taurospongin A has been achieved using, as a key step, a pi-allyltricarbonyliron lactone complex to control a highly stereoselective addition of a methyl group to a carbonyl unit located in the side chain of the complex.