185147-19-7Relevant academic research and scientific papers
3,4-Diaryl-5-hydroxyfuranones: Highly selective inhibitors of cyclooxygenase-2 with aqueous solubility
Black, W. Cameron,Brideau, Christine,Chan, Chi-Chung,Charleson, Stella,Cromlish, Wanda,Gordon, Robert,Grimm, Erich L.,Hughes, Gregory,Leger, Serge,Li, Chun-Sing,Riendeau, Denis,Therien, Michel,Wang, Zhaoyin,Xu, Li-Jing,Prasit, Petpiboon
, p. 1195 - 1198 (2007/10/03)
The introduction of a hydroxyl group into the 5-position of the diaryl furanone system provides highly selective inhibitors of cyclooxygenase-2. These molecules can be converted into their sodium salts which are water soluble, facilitating intravenous formulation. These salts show excellent potency in rat models of pain, fever and inflammation.
Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors
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, (2008/06/13)
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
