185198-40-7Relevant articles and documents
PYRIDINYL BASED APOPTOSIS SIGNAL-REGULATION KINASE INHIBITORS
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, (2018/09/12)
Apoptosis signal-regulating kinase 1 (ASK1) activation and signaling have been reported to play an important role in a broad range of diseases including neurodegenerative, cardiovascular, inflammatory, autoimmunity and metabolic disorders. Disclosed herein is the synthesis of pyridinyl derived therapeutic agents that function as inhibitors of ASK 1 as well as their pharmaceutical compositions and methods of use.
New synthetic route to 2-pyridones and its application toward the synthesis of (±)-ipalbidine
Sheehan, Scott M.,Padwa, Albert
, p. 438 - 439 (2007/10/03)
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