1852-38-6 Usage
Uses
Used in Pharmaceutical Industry:
Pregnenolone sulfate sodium salt is used as a sigma-1 receptor (σ1R) agonist for its potential role in modulating various cellular processes and as a ligand for transient receptor potential melastatin-3 (TRPM3) to influence calcium homeostasis and cellular signaling.
Used in Neuropharmacology:
As a neuroactive steroid, pregnenolone sulfate sodium salt is used to modulate the GABAA receptor, which plays a crucial role in regulating neuronal excitability and has implications in the treatment of various neurological and psychiatric disorders.
Used in Research Applications:
Pregnenolone sulfate sodium salt is utilized in research as a potent and efficacious modulator of the NMDA receptor, aiding in the study of glutamatergic neurotransmission and its role in cognitive function, memory, and neurodegenerative diseases.
Biochem/physiol Actions
Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.
Check Digit Verification of cas no
The CAS Registry Mumber 1852-38-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,5 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1852-38:
(6*1)+(5*8)+(4*5)+(3*2)+(2*3)+(1*8)=86
86 % 10 = 6
So 1852-38-6 is a valid CAS Registry Number.
