1852-41-1

Usage

Uses

Used in Scientific Research and Medical Studies:
Androsterone Sulfate Sodium Crystalline is used as a research compound for studying hormonal physiology and related medical conditions. Its water-soluble nature allows for easy utilization in laboratory experiments, making it a valuable tool for understanding the biological effects of androsterone.
Used in Pharmaceutical Applications:
Androsterone Sulfate Sodium Crystalline is used as an active pharmaceutical ingredient in the development of medications targeting hormonal imbalances and related health issues. Its crystalline form facilitates its incorporation into various drug formulations, enhancing its therapeutic potential.
Used in Hormone Replacement Therapy:
Androsterone Sulfate Sodium Crystalline can be used as a component in hormone replacement therapies, particularly for conditions related to male reproductive function and behavior. Its sulfate form allows for better absorption and utilization in the body, making it an effective option for hormone supplementation.
Used in Diagnostic Tests:
Androsterone Sulfate Sodium Crystalline can be employed in diagnostic tests to measure and monitor androsterone levels in the body. Its water-soluble nature makes it suitable for use in assays and other laboratory tests, aiding in the diagnosis and management of hormonal disorders.

Upstream product

• 53-41-8 cis-androsterone 

Relevant academic research and scientific papers

5α-Androst-16-en-3α-ol β-D-glucuronide, precursor of 5α-androst-16-en-3α-ol in human sweat

5α-Androst-16-en-3α-ol (α-androstenol) is an important contributor to human axilla sweat odor. It is assumed that α-andostenol is excreted from the apocrine glands via a H2O-soluble conjugate, and this precursor was formally characterized in this study for the first time in human sweat. The possible H2O-soluble precursors, sulfate and glucuronide derivatives, were synthesized as analytical standards, i.e., α-androstenol, β-androstenol sulfates, 5α-androsta-5,16-dien- 3β-ol (β-androstadienol) sulfate, α-androstenol β-glucuronide, α-androstenol α-glucuronide, β-androstadienol β-glucuronide, and α-androstenol β-glucuronide furanose. The occurrence of α-androstenol β-glucuronide was established by ultra performance liquid chromatography (UPLC)/MS (heated electrospray ionization (HESI)) in negative-ion mode in pooled human sweat, containing eccrine and apocrine secretions and collected from 25 female and 24 male underarms. Its concentration was of 79 ng/ml in female secretions and 241 ng/ml in male secretions. The release of α-androstenol was observed after incubation of the sterile human sweat or α-androstenol β-glucuronide with a commercial glucuronidase enzyme, the urine-isolated bacteria Streptococcus agalactiae, and the skin bacteria Staphylococcus warneri DSM 20316, Staphylococcus haemolyticus DSM 20263, and Propionibacterium acnes ATCC 6919, reported to have β-glucuronidase activities. We demonstrated that if α- and β-androstenols and androstadienol sulfates were present in human sweat, their concentrations would be too low to be considered as potential precursors of malodors; therefore, the H2O-soluble precursor of α-androstenol in apocrine secretion should be a β-glucuronide. Copyright