1852-50-2 Usage
General Description
Estriol-16beta-D-glucopyranosiduronic acid is a chemical compound that is a derivative of estriol, which is a naturally occurring estrogen hormone in the human body. Estriol-16beta-D-glucopyranosiduronic acid is a glucuronide conjugate of estriol, meaning that it is estriol that has been modified by the addition of glucuronic acid via a beta-D-glucopyranosiduronic linkage. Glucuronidation is a common metabolic pathway in the body that helps to detoxify and eliminate potentially harmful substances, and in the case of estriol-16beta-D-glucopyranosiduronic acid, it serves to make the hormone more water-soluble and easier to excrete. Estriol-16beta-D-glucopyranosiduronic acid has been studied for its potential role in hormone replacement therapy and its effects on estrogen receptor activity.
Check Digit Verification of cas no
The CAS Registry Mumber 1852-50-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,5 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1852-50:
(6*1)+(5*8)+(4*5)+(3*2)+(2*5)+(1*0)=82
82 % 10 = 2
So 1852-50-2 is a valid CAS Registry Number.
InChI:InChI=1/C24H32O9/c1-24-7-6-13-12-5-3-11(25)8-10(12)2-4-14(13)15(24)9-16(21(24)29)32-23-19(28)17(26)18(27)20(33-23)22(30)31/h3,5,8,13-21,23,25-29H,2,4,6-7,9H2,1H3,(H,30,31)
1852-50-2Relevant articles and documents
The synthesis of estriol 16- and 17-monoglucuronide from estriol
Wu, Yinqiu,Blackwell, Leonard F.
, p. 452 - 456 (1993)
An efficient and convenient procedure for the synthesis of estriol 16- and 17-monoglucuronides from estriol is described. This is achieved by the selective protection and deprotection of the hydroxy groups in estriol, Koenigs-Knorr reactions with methyl 1-bromo-1-deoxy-2,3,4-tri-O-acetyl-α-D-glucopyranuronate and subsequent hydrolysis. The products have been characterized by proton nuclear magnetic resonance (1H NMR), two-dimensional 1H homonuclear shift-correlated spectra (2D-COSY) and mass spectra. The selective Koenigs-Knorr reaction of the alcoholic hydroxyl group in the presence of a phenolic hydroxyl group is also reported. Keywords: steroids; estriol; estriol 16- and 17-glucuronides; selective protection; Koenigs-Knorr reaction; synthesis.
Syntheses of estriol monoglucuronides.
Nambara,Imai
, p. 1232 - 1238 (2007/10/10)
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