185211-24-9Relevant academic research and scientific papers
Fluorous l -Carbidopa Precursors: Highly Enantioselective Synthesis and Computational Prediction of Bioactivity
Granados, Albert,Olmo, Anna Del,Peccati, Francesca,Billard, Thierry,Sodupe, Mariona,Vallribera, Adelina
, p. 303 - 313 (2018)
New fluorous enantiopure (S)-α-aminated β-keto esters were prepared through a highly enantioselective electrophilic α-amination step in the presence of europium triflate and (R,R)-phenyl-pybox. These compounds are precursors of fluorinated analogues of l-
PYRAZOLONE DERIVATIVES AS NITROXYL DONORS
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Page/Page column 179; 195; 212, (2016/01/29)
The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY
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Paragraph 001166, (2013/08/28)
Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
ERβ ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives
Vu, An T.,Cohn, Stephen T.,Manas, Eric S.,Harris, Heather A.,Mewshaw, Richard E.
, p. 4520 - 4525 (2007/10/03)
A new class of estrogen receptor β (ERβ) ligands based on the 2-phenylquinoline scaffold was prepared. Several analogues with C4 substitution displayed high affinity (3-5 nM) and significant selectivity (up to 83-fold) for ERβ. The best compound, 13b, was profiled as a selective partial agonist for ERβ at 1 μM in a cell-based transcriptional assay. Uterine weight bioassay of 13b indicated no activation of ERα in vivo.
