185223-24-9Relevant academic research and scientific papers
Synthesis of acyclic and heterocyclic derivatives of 2-carboxyquinuclidine. Part VIII
Bulacinski, Andrzej Benedykt
, p. 217 - 220 (2007/10/03)
The 2-chlorocarbonylquinuclidine hydrochloride obtained from 2-carboxyquinuclidine hydrochloride was heated in benzene, in the presence of triethylamine, with the amines to give suitable piperazin-quinuclidinylcarboxyamides [I-X]. Some of the carboxyamides were reduced using LiAlH4 in diethyl ether and THF to the adequate piperazin-quinuclidinylmethylamines [XI-XV]. The structure of compounds obtained was confirmed by elementary analysis and IR spectra.
