185244-31-9Relevant academic research and scientific papers
CHEMICAL COMPOUNDS
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Page/Page column 39, (2008/06/13)
The present invention relates generally to novel therapeutic compounds and AXOR 109 agonists, and processes for the manufacture and use of the same.
Aryl sulfonamides as selective PDE4 inhibitors
Montana, John G.,Buckley, George M.,Cooper, Nicola,Dyke, Hazel J.,Gowers, Lewis,Gregory, Joanna P.,Hellewell, Paul G.,Kendall, Hannah J.,Lowe, Christopher,Maxey, Robert,Miotla, Jadwiga,Naylor, Robert J.,Runcie, Karen A.,Tuladhar, Bishwa,Warneck, Julie B. H.
, p. 2635 - 2640 (2007/10/03)
A series of novel selective phosphodiesterase 4 (PDE4) inhibitors has been developed which displays activity both in vitro and in vivo. These compounds possess good selectivity for the catalytic site of PDE4 over the high affinity Rolipram binding site. In vivo studies demonstrate a reduced propensity to display the emetic side effects which are commonly observed with PDE4 inhibitors.
