185244-55-7

Basic information

• Product Name: 4-bromo-2,3-dihydro-7-methoxybenzofuran-2-spiro-1'-cyclopentane
• Synonyms: 4-bromo-2,3-dihydro-7-methoxybenzofuran-2-spiro-1'-cyclopentane
• CAS NO: 185244-55-7
• Molecular Weight: 283.165
• Mol File: 185244-55-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-bromo-2,3-dihydro-7-methoxybenzofuran-2-spiro-1'-cyclopentane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2,3-dihydro-7-methoxybenzofuran-2-spiro-1'-cyclopentane(185244-55-7)
• EPA Substance Registry System: 4-bromo-2,3-dihydro-7-methoxybenzofuran-2-spiro-1'-cyclopentane(185244-55-7)

Safety Data

• Hazardous Substances Data: 185244-55-7(Hazardous Substances Data)

Upstream product

• 37942-01-1 5-bromo-2-methoxyphenol 

Relevant articles and documents

Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones

A series of 4-aryl-substituted cis-4a,5,8,8a-tetra- and cis-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-ones with high inhibitory activity toward cAMP-specific phosphodiesterase (PDE4) was synthesized. To study structure-activity relationships various substituents were introduced to the 2-, 3-, and 4-positions of the 4-phenyl ring. Substitution at the 4-position of the phenyl ring was restricted to a methoxy group, probably due to unfavorable steric interactions of larger groups with the binding site. The introduction of many alkoxy substituents including distinct ring systems and functional groups was allowed to the 3-position. It was found that in general the cis-4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones are more potent than their hexahydrophthalic counterparts, the best activity residing in (4-imidazol-1-yl-phenoxy)butoxy analogue 16o (pIC50 = 9.7).